Method for the preparation of citalopram
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United States of America Patent
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May 8, 2001
Grant Date -
N/A
app pub date -
Jan 7, 2000
filing date -
Jul 8, 1997
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Abstract
A method for the preparation of citalopram comprising the steps of reacting a compound of Formula (IV) wherein R.sup.1 is C.sub.1-6 alkyl and X is O or NH, successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent of 3-halogen-N,N-dimethylpropylamine, respectively, effecting ring-closure of the resulting compound of Formula (V) wherein R.sup.1 and X are as defined above, and converting the resulting 1,3-dihydroisobenzofuran compound to the corresponding 5-cyano derivative, i.e. citalopram.
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