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Abstract

The invention provides articles of manufacture comprising substantially non-immunogenic soft and bone tissue xenografts for implantation into humans. The invention further provides methods for preparing soft and bone tissue xenografts by removing at least a portion of a soft or bone tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; exposing the xenograft to an aldehyde in an amount ranging from about 0.01% to about 0.10%; and digesting the xenograft with a glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a soft or bone tissue xenograft for implantation into a human including a portion of a soft or bone tissue from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. The extracellular components also have an aldehyde in an amount ranging from about 0.01% to about 0.10% crosslinking the proteins of the extracellular components. Each of the xenografts of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft or bone tissue.

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First Claim