Cell-specific contrast agent and gene delivery vehicles
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United States of America Patent
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May 15, 2001
Grant Date -
N/A
app pub date -
Oct 12, 1994
filing date -
Oct 12, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
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