US Patent No: 6,232,297

Number of patents in Portfolio can not be more than 2000

Methods and compositions for treating inflammatory response

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Importance

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Abstract

Compounds and methods are provided to treat inflammatory conditions with certain A.sub.2A adenosine receptor antagonists.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PATENT FOUNDATION, VIRGINIA, UNIVERSITY OFCHARLOTTESVILLE, VA2

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Linden, Joel M Charlottesville, VA 45 589
MacDonald, Timothy Charlottesville, VA 15 162
Okusa, Mark Charlottesville, VA 4 66
Sarembock, Ian J Charlottesville, VA 5 66
Sullivan, Gail W Charlottesville, VA 32 565

Cited Art

Patent Info (Count) # Cites Year
 
ADERIS PHARMACEUTICALS, INC. (3)
5,140,015 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents 47 1990
5,278,150 2-hydrazoadenosines and their utility for the treatmeat of vascular conditions 39 1992
RE36494 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents 23 1993
 
BIOCHEM PHARMA INC. (2)
5,756,706 Processes for the diastereoselective synthesis of nucleoside analogues 40 1994
5,696,254 Processes for the diastereoselective synthesis of nucleoside analogues 41 1994
 
MERCK FROSST CANADA LTD. (2)
6,020,339 Aryl furan derivatives as PDE IV inhibitors 34 1998
6,034,089 Aryl thiophene derivatives as PDE IV inhibitors 32 1998
 
NEW YORK UNIVERSITY (2)
5,932,558 Adenosine receptor agonists for the promotion of wound healing 28 1996
6,020,321 Adenosine receptor agonists for the promotion of wound healing 24 1999
 
UNIVERSITY OF VIRGINIA (2)
5,272,153 Method of inhibiting the activity of leukocyte derived cytokines 42 1992
5,877,180 Method for treating inflammatory diseases with A.sub.2a adenosine receptor agonists 61 1994
 
YAMASA SHOYU KABUSHIKI KAISHA (2)
4,956,345 2-alkynyladenosines as antihypertensive agents 51 1988
5,189,027 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases 49 1991
 
AMERICAN HOME PRODUCTS CORPORATION (1)
5,124,455 Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents 75 1990
 
ANGELLO, PAUL S., 1858 PALISADES TERRACE DRIVE, LAKE OSWEGO, OREGON 97034 (1)
4,824,660 Method of determining the viability of tissue in an organism 32 1985
 
BURROUGHS WELLCOME CO. (1)
4,879,296 Xanthine derivatives 50 1986
 
BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (1)
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CARDIOKINE, INC. (1)
5,998,386 Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue 33 1997
 
ICOS CORPORATION (1)
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ITEM DEVELOPMENT AB (1)
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KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (1)
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NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
5,298,508 Irreversible inhibitors of adenosine receptors 33 1992
 
PUREF, LLC (1)
6,004,945 Use of adenosine compounds to relieve pain 24 1995
 
SCHERING AKTIENGESELLSCHAFT (1)
4,193,926 4-(Polyalkoxy phenyl)-2-pyrrolidones 99 1976
 
SCHERING CORPORATION (1)
5,593,975 Adenosine derivatives having A.sub.2 agonist activity 52 1995
 
TEVA PHARMACEUTICAL INDUSTRIES LTD. (1)
5,565,462 Composition for topical treatment of psoriasis and atopic dermatitis comprising a xanthine derivative 26 1994
 
THE UNIVERSITY OF PATENT FOUNDATION (1)
5,854,081 Stable expression of human A.sub.2B adenosine receptors, and assays employing the same 31 1996
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
5,668,139 A1 adenosine receptor agonists and antagonists 22 1995
 
UNIVERSITY OF ROCHESTER, ROCHESTER, NEW YORK 14627, A NOT-FOR-PROFIT CORP. OF NEW YORK (1)
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UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION, THE, THE TOWERS OFFICE BUILDING, SUITE 6211, 1224 W. MAIN STREET, CHARLOTTESVILLE, VA 22903 A CORP OF VA (1)
5,096,906 Method of inhibiting the activity of leukocyte derived cytokines 79 1990
 
UNIVERSITY OF VIRGINIA, A CORP. OF DE (1)
4,965,271 Method of inhibiting the activity of leukocyte derived cytokines 73 1987
 
WULFING; JOHANN A. (1)
4,242,345 7-(Oxoalkyl)-1,3-dialkyl xanthines, and medicaments containing them 29 1978

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
UNIVERSITY OF VIRGINIA (13)
7,732,484 receptor allosteric enhancers to manipulate angiogenesis 0 2001
7,214,665 2-propynyl adenosine analogs having A.sub.2A agonist activity and compositions thereof 17 2002
7,427,606 Method to reduce inflammatory response in transplanted tissue 11 2004
7,605,143 agonist activity 9 2005
7,576,069 2-polycyclic propynyl adenosine analogs having A2A agonist activity 8 2005
7,442,687 2-polycyclic propynyl adenosine analogs having A2A agonist activity 7 2005
7,378,400 Method to reduce an inflammatory response from arthritis 13 2005
8,178,509 Method to treat sickle cell disease 0 2007
7,737,127 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof 5 2007
8,188,063 modulators to treat spinal cord injury 0 2007
7,989,431 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity 3 2009
7,875,595 2-polycyclic propynyl adenosine analogs having A2A agonist activity 4 2009
8,158,604 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof 0 2010
 
OTSUKA PHARMACEUTICAL CO., LTD. (2)
7,834,002 4-amino-5-cyanopyrimidine derivatives 0 2005
7,989,446 4-amino 5-cyanopyrimidine derivatives 0 2010
 
PFIZER INC. (2)
6,326,359 Adenosine A2A receptor agonists as antiinflammatory agents 25 1999
6,900,309 Purine derivatives 2 2000
 
PURDUE RESEARCH FOUNDATION (2)
7,837,987 Methods and compositions for treating mammalian nerve tissue injuries 0 2002
7,792,576 Method of treatment for central nervous system injury 1 2007
 
TROVIS PHARMACEUTICALS, LLC (2)
8,293,720 R agonists 0 2008
8,263,762 R agonists 0 2010
 
GLAXO GROUP LIMITED (1)
7,985,740 Purine derivatives as agonists of the adenosine A2A receptor 0 2006
 
NEW YORK UNIVERSITY (1)
6,555,545 Adenosine A2A receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver 0 2001
 
PGX HEALTH, LLC (1)
7,671,191 Methods for preparing 2-alkynyladenosine derivatives 0 2007
 
PGXHEALTH, LLC (1)
8,058,259 R agonists 3 2008
 
SMITHKLINE BEECHAM CORPORATION (1)
6,407,076 Adenosine analogues and related method of treatment 14 2000