Methods of preparing new taxoids and pharmaceutical compositions containing them
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United States of America Patent
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May 15, 2001
Grant Date -
N/A
app pub date -
Mar 17, 2000
filing date -
Mar 25, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods of preparing new taxoids of general formula (I) are presented: ##STR1## in which: R.sub.4 represents an alkanoyloxy radical in which the alkanoyl portion contains 2 to 6 carbon atoms in an unbranched or branched chain, this radical unsubstituted or substituted with one or more halogen atoms, an alkoxy radical containing 1 to 4 carbon atoms, or alternatively R.sub.4 represents a cycloalkanoyloxy radical in which the cycloalkanoyl portion contains 4 to 8 carbon atoms, or alternatively R.sub.4 represents a benzoyloxy radical; R.sub.5 represents an alkoxy radical containing 1 to 4 carbon atoms, substituted by an alkylthio radical containing 1 to 4 carbon atoms; and Z represents a hydrogen atom or a radical of general formula: ##STR2##
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