Ultrasound enhancement of transdermal transport

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United States of America Patent

PATENT NO 6234990
SERIAL NO

08885931

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while causing less pain. Alternatively, ultrasound energy is applied through a vibrating element positioned just contacting, above or extending into the skin. Use of the element facilitates extraction of analyte and may enhance drug delivery. A two step noninvasive method involves application of ultrasound to increase skin permeability and removal of ultrasound followed by transdermal transport that can be further enhanced using a physical enhancer.

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Patent Owner(s)

  • SONTRA MEDICAL, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Davis, Matthew Boston, MA 208 5631
Kost, Joseph Omer, IL 38 3836
Mitragotri, Samir S Cambridge, MA 20 3696
Pishko, Michael Bryan, TX 6 810
Rowe, Stephen Wellesley, MA 12 848

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