HTLV-1 probes for use in solution phase sandwich hybridization assays
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United States of America Patent
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May 22, 2001
Grant Date -
N/A
app pub date -
Apr 24, 1995
filing date -
Dec 23, 1991
priority date (Note) -
Expired
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Abstract
Synthetic oligonucleotides which are useful as probes in a solution phase sandwich hybridization assay for the detection of HTLV-1 are described. The oligonucleotides have a first segment comprising a nucleotide sequence substantially complementary to a segment of HTLV-1 nucleic acid, and a second segment comprising a nucleotide sequence which is not complementary to HTLV-1 nucleic acid but is substantially complementary to an oligonucleotide unit of a nucleic acid multimer or to an oligonucleotide bound to a solid phase. Amplified nucleic acid hybridization assays using the probes are exemplified.
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