.alpha.1,2 fucosyltransferase
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United States of America Patent
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May 29, 2001
Grant Date -
N/A
app pub date -
Nov 2, 1999
filing date -
Nov 4, 1998
priority date (Note) -
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Abstract
A bacterial .alpha.1,2-fucosyltransferase gene and deduced amino acid sequence is provided. The gene is useful for preparing .alpha.1,2-fucosyltransferase polypeptide, and active fragment thereof, which can be used in the production of oligosaccharides such as Lewis X, Lewis Y, Lewis B and H type 1, which are structurally similar to certain tumor-associated carbohydrate antigens found in mammals. These product glycoconjugates also have research and diagnostic utility in the development of assays to detect mammalian tumors.
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