Apparatus for electroporation mediated delivery of drugs and genes
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United States of America Patent
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Jun 5, 2001
Grant Date -
N/A
app pub date -
Oct 22, 1998
filing date -
Aug 1, 1997
priority date (Note) -
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Abstract
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode having a 'keying' element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. A disposable needle tip array may be implemented.
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