US Patent No: 6,241,701
Number of patents in Portfolio can not be more than 2000
Apparatus for electroporation mediated delivery of drugs and genes
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Jun 5, 2001
Issued date -
Oct 22, 1998
filing date -
09/177,678
serial no -
In Force
status
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Abstract
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode having a "keying" element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. A disposable needle tip array may be implemented.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,019,034 Control of transport of molecules across tissue using electroporation | 203 | 1989 | |
| 5,547,467 Method for rapid temporal control of molecular transport across tissue | 50 | 1993 | |
| 5,389,069 Method and apparatus for in vivo electroporation of remote cells and tissue | 149 | 1993 | |
| 5,749,847 Delivery of nucleotides into organisms by electroporation | 49 | 1995 | |
| 5,667,491 Method for rapid temporal control of molecular transport across tissue | 40 | 1995 | |
| 6,002,961 Transdermal protein delivery using low-frequency sonophoresis | 106 | 1995 | |
| 5,814,599 Transdermal delivery of encapsulated drugs | 235 | 1995 | |
| 6,041,253 Effect of electric field and ultrasound for transdermal drug delivery | 243 | 1996 | |
| 5,983,131 Apparatus and method for electroporation of tissue | 109 | 1996 | |
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| 5,304,120 Electroporation method and apparatus for insertion of drugs and genes into endothelial cells | 117 | 1992 | |
| 5,273,525 Injection and electroporation apparatus for drug and gene delivery | 89 | 1992 | |
| 5,507,724 Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells | 108 | 1994 | |
| 5,869,326 Electroporation employing user-configured pulsing scheme | 114 | 1996 | |
| 5,968,006 Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes | 54 | 1998 | |
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| 6,041,252 Drug delivery system and method | 119 | 1995 | |
| 6,010,613 Method of treating materials with pulsed electrical fields | 61 | 1995 | |
| 5,873,849 Electrodes and electrode arrays for generating electroporation inducing electrical fields | 92 | 1997 | |
| 6,078,490 Method of treating materials with pulsed electrical fields | 8 | 1999 | |
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| 5,536,267 Multiple electrode ablation apparatus | 531 | 1994 | |
| 5,980,517 Cell necrosis apparatus | 84 | 1998 | |
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| 5,814,476 Process for the production of stochastically-generated transcription or translation products | 161 | 1995 | |
| 5,817,483 Process for the production of stochastically-generated peptides,polypeptides or proteins having a predetermined property | 134 | 1995 | |
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| 5,879,891 Transformation of saccharomyces cerevisiae by electroporation | 17 | 1997 | |
| 5,908,753 Transformation of Candida albicans by electroporation | 13 | 1997 | |
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| 5,702,359 Needle electrodes for mediated delivery of drugs and genes | 135 | 1995 | |
| 5,810,762 Electroporation system with voltage control feedback for clinical applications | 66 | 1997 | |
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| 5,807,308 Method and apparatus for treatment of air way obstructions | 64 | 1996 | |
| 5,718,702 Uvula, tonsil, adenoid and sinus tissue treatment device and method | 163 | 1996 | |
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| 5,498,238 Simultaneous angioplasty and phoretic drug delivery | 105 | 1993 | |
| 5,634,899 Simultaneous cardiac pacing and local drug delivery method | 141 | 1994 | |
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| 5,800,378 Medical probe device and method | 155 | 1996 | |
| 5,807,309 Transurethral needle ablation device and method for the treatment of the prostate | 41 | 1997 | |
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| 6,040,184 Method for more efficient electroporation | 16 | 1999 | |
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| 5,995,869 Reduction of skin sensitization in electrotransport drug delivery | 57 | 1997 | |
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| 5,868,740 Method for volumetric tissue ablation | 242 | 1995 | |
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| 5,328,451 Iontophoretic device and method for killing bacteria and other microbes | 65 | 1991 | |
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| 5,439,440 Electroporation system with voltage control feedback for clinical applications | 130 | 1993 | |
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| 5,468,223 Electrochemotherapy | 58 | 1992 | |
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| 5,507,802 Method of mapping and/or ablation using a catheter having a tip with fixation means | 86 | 1994 | |
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| 5,674,267 Electric pulse applicator using pairs of needle electrodes for the treatment of biological tissue | 116 | 1995 | |
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| 5,058,605 Method and device for the controlled local, non-invasive application of DC pulses to human and animal tissues | 87 | 1990 | |
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| 5,088,977 Electrical transdermal drug applicator with counteractor and method of drug delivery | 38 | 1988 | |
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| 5,874,268 Method of introducing exogenous compounds into cells by electroporation and apparatus for same | 17 | 1996 | |
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| 4,907,601 Electrotherapy arrangement | 51 | 1988 | |
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| 5,944,715 Electrosurgical instrument | 239 | 1996 | |
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| 5,789,213 Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses | 16 | 1995 | |
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| 4,663,292 High-voltage biological macromolecule transfer and cell fusion system | 30 | 1984 | |
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| 6,110,161 Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle | 23 | 1998 | |
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| 5,720,921 Flow electroporation chamber and method | 59 | 1995 | |
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| 5,780,052 Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell | 28 | 1995 | |
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| 6,001,617 Electroporation device and method of use | 22 | 1990 | |
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| 5,964,726 Apparatus and method for efficient incorporation of molecules into cells | 66 | 1997 | |
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| 5,994,127 In vivo production and delivery of erythropoietin or insulinotropin for gene therapy | 34 | 1994 | |
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| 5,911,223 Introduction of modifying agents into skin by electroporation | 70 | 1996 | |
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| 5,993,434 Method of treatment using electroporation mediated delivery of drugs and genes | 114 | 1995 | |
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| 5,215,088 Three-dimensional electrode device | 185 | 1989 | |
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| 5,554,110 Medical ablation apparatus | 185 | 1994 | |
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| 5,786,454 Modified SH2 domains | 24 | 1994 | |
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| 4,262,672 Acupuncture instrument | 68 | 1978 | |
| 5,425,752 Method of direct electrical myostimulation using acupuncture needles | 36 | 1993 | |
| 5,823,993 Computer controlled drug injection system and method | 47 | 1995 | |
| 5,845,646 System and method for treating select tissue in a living being | 116 | 1996 | |