Compositions for increasing the MRI contrast in visualizing the digestive tract of patients
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United States of America Patent
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Jun 5, 2001
Grant Date -
N/A
app pub date -
Dec 28, 1999
filing date -
Dec 23, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R.sup.1 R.sup.2).dbd.CR.sup.3 --CO--Z--Z (1) and/or C(R.sup.1 R.sup.2).dbd.CR.sup.3 --CO--Z--Z--Z--CO--CR.sup.3.dbd.C(R.sup.1 R.sup.2) (2) in monomer, oligomer, homopolymer and copolymer forms, in which the R.sup.1, R.sup.2 and R.sup.3 represent H or saturated or unsaturated C.sub.1-10 aliphatic radicals optionally substituted by one or more OH groups; Z is a covalent bond or a linker spacer and A is a moiety capable of fixing a paramagnetic metal by chelation. Compounds of type (1) useful in the present invention are, for instance the polyalkylene-aminopolycarboxylic acids such as NTA, EDTA, DTPA, DOTA and like structures, possibly involving additional substituents; an example is the compound BOPTA which is a DTPA derivative carrying a benzyloxypropyl group.
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