Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
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United States of America Patent
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Jun 5, 2001
Grant Date -
N/A
app pub date -
Jun 26, 1998
filing date -
Jun 26, 1998
priority date (Note) -
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Abstract
The present invention provides compositions containing corticosteroid compounds as active agents for the treatment of ailments and diseases of the respiratory tract, particularly the lungs, by way of nasal and pulmonary administration. The corticosteroid compounds are present in a dissolved state in the compositions. The compositions can be formulated in a concentrated, essentially non-aqueous form for storage or in a diluted, aqueous-based form for ready delivery. In a preferred embodiment, the corticosteroid composition contains an ethoxylated derivative of vitamin E and/or a polyethylene glycol fatty acid ester as the high-HLB surfactant present in the formulation. The compositions are ideally suited for inhaled delivery with a nebulizer or for nasal delivery.
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