US Patent No: 6,245,319
Number of patents in Portfolio can not be more than 2000
Colloidal dispersions of perfluoropentane
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Jun 12, 2001
Issued date -
Mar 24, 2000
filing date -
09/535,165
serial no -
In Force
status
Importance
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Abstract
Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the temperature of the animal to be imaged and which therefore undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to the animal. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,844,882 Concentrated stabilized microbubble-type ultrasonic imaging agent | 213 | 1987 | |
| 5,409,688 Gaseous ultrasound contrast media | 164 | 1992 | |
| 5,558,855 Phase shift colloids as ultrasound contrast agents | 97 | 1993 | |
| 5,393,524 Methods for selecting and using gases as ultrasound contrast media | 159 | 1993 | |
| 5,529,766 Contrast agents | 88 | 1993 | |
| 5,536,490 Contrast agents | 97 | 1993 | |
| 5,558,853 Phase shift colloids as ultrasound contrast agents | 136 | 1994 | |
| 5,562,893 Gas-filled microspheres with fluorine-containing shells | 82 | 1994 | |
| 5,674,468 Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons | 19 | 1994 | |
| 5,637,289 Contrast agents, consisting of galactose particles | 11 | 1994 | |
| 5,558,856 Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging | 129 | 1994 | |
| 5,618,514 Diagnostic and contrast agent | 16 | 1994 | |
| 5,558,854 Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas | 99 | 1995 | |
| 5,558,094 Methods for using persistent gases as ultrasound contrast media | 92 | 1995 | |
| 5,718,884 Microbubble-based contrast agents with crosslinked and reduced proteinaceous shells | 38 | 1995 | |
| 5,670,135 Ultrasonic contrast agent comprising carbohydrate particles | 13 | 1995 | |
| 5,614,169 Contrast agents, consisting of galactose particles and an amphilic carboxylic acid | 58 | 1995 | |
| 5,648,062 Contrast agents consisting of galactose particles | 8 | 1995 | |
| 5,567,413 Flexible amphiphilic microbubbles for ultrasound | 90 | 1995 | |
| 5,676,925 Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons | 56 | 1995 | |
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| 5,088,499 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 181 | 1990 | |
| 5,205,290 Low density microspheres and their use as contrast agents for computed tomography | 116 | 1991 | |
| 5,228,446 Gas filled liposomes and their use as ultrasonic contrast agents | 89 | 1991 | |
| 5,123,414 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 151 | 1991 | |
| 5,230,882 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 89 | 1992 | |
| 5,352,435 Ionophore containing liposomes for ultrasound imaging | 116 | 1992 | |
| 5,281,408 Low density microspheres and their use as contrast agents for computed tomography | 136 | 1993 | |
| 5,469,854 Methods of preparing gas-filled liposomes | 165 | 1993 | |
| 5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 169 | 1993 | |
| 5,348,016 Apparatus for preparing gas filled liposomes for use as ultrasonic contrast agents | 31 | 1993 | |
| 5,456,900 Low density microspheres and their use as contrast agents for computed tomography | 65 | 1993 | |
| 5,585,112 Method of preparing gas and gaseous precursor-filled microspheres | 170 | 1993 | |
| 5,456,901 Liposomes as contrast agents for ultrasonic imaging | 7 | 1995 | |
| 5,705,187 Compositions of lipids and stabilizing materials | 60 | 1995 | |
| 5,547,656 Low density microspheres and their use as contrast agents for computed tomography, and in other applications | 126 | 1995 | |
| 5,527,521 Low density microspheres and suspensions and their use as contrast agents for computed tomography and in other applications | 85 | 1995 | |
| 5,571,497 Liposomes as contrast agents for ultrasonic imaging and apparatus and methods for preparing the same | 7 | 1995 | |
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| 4,957,656 Continuous sonication method for preparing protein encapsulated microbubbles | 202 | 1988 | |
| 5,107,842 Method of ultrasound imaging of the gastrointestinal tract | 92 | 1991 | |
| 5,401,493 Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same | 29 | 1993 | |
| 5,716,597 Emulsions as contrast agents and method of use | 60 | 1993 | |
| 5,385,147 Method of ultrasonic imaging of the gastrointestinal tract and upper abdominal organs using an orally administered negative contrast medium | 20 | 1993 | |
| 5,552,133 Method of making encapsulated gas microspheres useful as an ultrasonic imaging agent | 116 | 1994 | |
| 5,536,489 Emulsions as contrast agents and method of use | 123 | 1995 | |
| 5,606,973 Liquid core microdroplets for ultrasound imaging | 63 | 1995 | |
| 5,730,955 Process for making gas-filled microspheres containing a liquid hydrophobic barrier | 4 | 1995 | |
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| 4,276,885 Ultrasonic image enhancement | 270 | 1979 | |
| 4,265,251 Method of determining pressure within liquid containing vessel | 133 | 1979 | |
| 4,442,843 Microbubble precursors and methods for their production and use | 210 | 1981 | |
| 4,466,442 Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics | 265 | 1982 | |
| 4,657,756 Microbubble precursors and apparatus for their production and use | 232 | 1983 | |
| 4,681,119 Method of production and use of microbubble precursors | 197 | 1986 | |
| 5,141,738 Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof | 165 | 1991 | |
| 5,730,954 Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent | 15 | 1994 | |
| 5,501,863 Contrast media synthesized from polyaldehydes | 112 | 1995 | |
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| 4,865,836 Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport | 153 | 1986 | |
| 4,987,154 Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use | 131 | 1987 | |
| 4,927,623 Dissolution of gas in a fluorocarbon liquid | 161 | 1988 | |
| 5,080,885 Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport | 55 | 1989 | |
| 5,284,645 Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems | 21 | 1989 | |
| 4,993,415 Magnetic resonance imaging with perfluorocarbon hydrides | 114 | 1990 | |
| 5,344,393 Use of synthetic oxygen carriers to facilitate oxygen delivery | 45 | 1992 | |
| 5,344,930 Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties | 90 | 1993 | |
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| 5,711,933 Method of making polymeric gas or air filled microballoons for ultrasonic echography | 89 | 1994 | |
| 5,531,980 Stable microbubbles suspensions injectable into living organisms | 93 | 1994 | |
| 5,578,292 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof | 74 | 1995 | |
| 5,567,414 Stable microbubbles suspensions injectable into living organisms | 92 | 1995 | |
| 5,658,551 Stable microbubbles suspensions injectable into living organisms | 32 | 1995 | |
| 5,643,553 Stable microbubbles suspensions injectable into living organisms | 94 | 1995 | |
| 5,688,490 Mucoadhesive compositions for increasing the ultrasonic image contrast of the digestive tract | 109 | 1996 | |
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| 5,271,928 Stable microbubbles suspensions injectable into living organisms | 164 | 1991 | |
| 5,413,774 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof | 132 | 1992 | |
| 5,380,519 Stable microbubbles suspensions injectable into living organisms | 149 | 1993 | |
| 5,445,813 Stable microbubble suspensions as enhancement agents for ultrasound echography | 96 | 1993 | |
| 5,556,610 Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method | 150 | 1994 | |
| 5,597,549 Stable microbubble suspensions as enhancement agents for ultrasound echography | 14 | 1995 | |
| 5,686,060 Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography | 64 | 1995 | |
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| 5,605,673 Stabilized microbubble compositions for ultrasound | 95 | 1994 | |
| 5,540,909 Harmonic ultrasound imaging with microbubbles | 139 | 1994 | |
| 5,639,443 Stabilized microbubble compositions | 92 | 1995 | |
| 5,626,833 Ultrasound imaging method using microbubbles | 65 | 1995 | |
| 5,695,741 Stable microbubble precursors | 11 | 1995 | |
| 5,720,938 Systems for the formation of microbubbles | 7 | 1995 | |
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| 5,209,720 Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes | 116 | 1991 | |
| 5,733,572 Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles | 147 | 1994 | |
| 5,639,442 Contrast media for ultrasonic imaging | 5 | 1995 | |
| 5,714,528 Contrast media for ultrasonic imaging | 4 | 1995 | |
| 5,714,529 Contrast media for ultrasonic imaging | 4 | 1995 | |
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| 5,196,183 Contrast agents for ultrasound imaging | 111 | 1991 | |
| 5,354,549 Iodinated esters | 73 | 1991 | |
| 5,558,857 Contrast agents | 33 | 1993 | |
| 5,559,266 Iodinated esters | 38 | 1995 | |
| 5,693,321 Polymers containing diester units | 6 | 1995 | |
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| 5,567,415 Ultrasound contrast agents and methods for their manufacture and use | 83 | 1994 | |
| 5,578,291 Method and composition for optimizing left ventricular videointensity in echocardiography | 8 | 1994 | |
| 5,560,364 Suspended ultra-sound induced microbubble cavitation imaging | 147 | 1995 | |
| 5,701,899 Perfluorobutane ultrasound contrast agent and methods for its manufacture and use | 76 | 1995 | |
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| 5,508,021 Non-fluorinated polymeric shells for medical imaging | 86 | 1994 | |
| 5,505,932 Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging | 125 | 1995 | |
| 5,512,268 Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof | 86 | 1995 | |
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| 4,572,203 Contact agents for ultrasonic imaging | 251 | 1983 | |
| 4,718,433 Contrast agents for ultrasonic imaging | 238 | 1985 | |
| 4,774,958 Ultrasonic imaging agent and method of preparation | 227 | 1987 | |
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| 5,425,366 Ultrasonic contrast agents for color Doppler imaging | 220 | 1993 | |
| 5,611,344 Microencapsulated fluorinated gases for use as imaging agents | 42 | 1996 | |
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| 5,487,390 Gas-filled polymeric microbubbles for ultrasound imaging | 126 | 1994 | |
| 5,562,099 Polymeric microparticles containing agents for imaging | 20 | 1994 | |
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| 4,544,545 Liposomes containing modified cholesterol for organ targeting | 354 | 1983 | |
| 4,900,540 Lipisomes containing gas for ultrasound detection | 179 | 1983 | |
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| 5,155,215 Polychelating agents for image and spectral enhancement (and spectral shift) | 114 | 1990 | |
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| 4,895,876 Concentrated stable fluorochemical aqueous emulsions containing triglycerides | 56 | 1987 | |
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| 5,637,564 Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems | 4 | 1995 | |
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| 5,599,523 Echo contrast agent | 25 | 1994 | |
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| 4,985,550 Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants | 85 | 1987 | |
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| 4,832,941 Contrast medium for ultrasonic examinations and process for its preparation | 81 | 1986 | |
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| 4,684,479 Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures | 174 | 1985 | |
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| 5,149,319 Methods for providing localized therapeutic heat to biological tissues and fluids | 174 | 1990 | |
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| 5,137,928 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents | 142 | 1991 | |
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| 5,352,436 Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same | 70 | 1993 | |
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| 5,350,571 Emulsions of highly fluorinated organic compounds | 79 | 1992 | |
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| 5,403,575 Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them | 24 | 1991 | |
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| 5,171,755 Emulsions of highly fluorinated organic compounds | 113 | 1988 | |
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| 4,859,363 Emulsions of perfluorocarbons in aqueous media | 47 | 1988 | |
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| 5,078,146 Ultrasonic diagnosis apparatus | 26 | 1990 | |
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| 5,260,496 Process for separating mixtures of prefluorinated hydrocarbon compounds | 23 | 1992 | |
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| 5,406,950 Inhalable contrast agent | 31 | 1993 | |
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| 5,114,703 Percutaneous lymphography using particulate fluorocarbon emulsions | 135 | 1990 | |
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| 5,147,631 Porous inorganic ultrasound contrast agents | 185 | 1991 | |
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| 4,533,254 Apparatus for forming emulsions | 245 | 1984 | |
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| 5,653,959 Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients | 6 | 1994 | |
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| 4,767,610 Method for detecting abnormal cell masses in animals | 37 | 1984 | |
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| 5,869,538 Method for enhancing transport of gases to tissues | 8 | 1996 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Dec 12, 2012 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |