Mutated herpes simplex virus type 1 thymidine kinases and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6245543
SERIAL NO

09338308

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.

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Patent Owner(s)

  • BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Compadre, Cesar 7215 Gable Dr., Little Rock, AR 72205 14 96
Drake, Richard 52 White Oak, Little Rock, AR 72227 5 39
Hinds, Trenton Ross Univeristy School of Medicine P.O. Box 266, Portsmouth Commonwealth of Dominica West Indies, AG 3 13
Hurlburt, Barry 612 Parkway Pl., Little Rock, AR 72211 3 13
Rechtin, Tammy 8 Lake Ridge, Birmingham, AL 35216 3 13

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