Targeted site specific antisense oligodeoxynucleotide delivery method
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United States of America Patent
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Jun 12, 2001
Grant Date -
N/A
app pub date -
Jul 13, 1998
filing date -
Mar 12, 1996
priority date (Note) -
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Abstract
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in utility for agents such as oligonucleotides which are plagued with problems in reaching targeted sites in necessary therapeutic levels. The delivery system includes gas-filled microbubbles formed in a nitrogen-free environment. Microbubbles formed through sonication in a nitrogen-free environment are smaller and more stable than microbubbles sonicated in the presence of room air.
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