Compositions and methods for tolerization in immune complex-mediated disease progression
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United States of America Patent
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Jun 12, 2001
Grant Date -
N/A
app pub date -
Apr 26, 1999
filing date -
Apr 27, 1998
priority date (Note) -
Expired
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Abstract
Methods and compositions are provided for tolerizing shed antigen-specific B cells involved in an immune complex-mediated disease progression. The composition comprises a substantially non-immunogenic carrier molecule to which is linked carbohydrate chains containing a suppressive amount of a repeated, antigenic carbohydrate determinant derived from a shed antigen of interest. In a method of tolerizing shed antigen-specific B cells involved in an immune complex-mediated disease progression, administered to an individual is a therapeutically effective amount of the composition which, when contacting the shed antigen-specific B cells, induces tolerization of the shed antigen-specific B cells.
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