Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
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United States of America Patent
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Jun 12, 2001
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N/A
app pub date -
Sep 9, 1996
filing date -
May 13, 1994
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Abstract
The present invention provides a method for the treatment of diseases by the decomposition of peroxynitrite, preferably decomposition to benign products, comprising the use of a complex which is a selected ligand structure providing a complexed metal such as Mn, Fe, Ni and V transition metals. The method of use, as well as novel pharmaceutical compositions therefor, are for the treatment of diseases advantageously affected by decomposition of peroxynitrite ed at a rate over the natural background rate of decay of peroxynitrite in humans suffering from the disease which comprises administration of an amount of a complex, in dosage unit form, which is effective for such acceleration of the decomposition of peroxynitrite .
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