Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
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United States of America Patent
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Jun 12, 2001
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N/A
app pub date -
Aug 13, 1999
filing date -
Aug 21, 1998
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Abstract
A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of dissolving azithromycin in isopropanol, followed by the slow addition of water to the organic solution.
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