Programmed release ambroxol--HCl dosage forms
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United States of America Patent
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-
Jun 26, 2001
Grant Date -
N/A
app pub date -
Jan 30, 1995
filing date -
Dec 11, 1991
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Programmed-release ambroxol.multidot.HCl pharmaceutical dosage forms, adopted to maintain a therapeutically effective plasma level thereof for about 24 hours, comprise a plurality of inert core microgranules of a variety of particle sizes ranging from 0.3 to 1.2 mm, such inert core microgranules being coated with alternating microlayers of (1) micronized ambroxol hydrochloride active agent and (2) delayed-release film material, such coated microgranules including an external microlayer of delayed-release film material, and such coated mi.crogranules having particle sizes ranging from 0.6 to 1.5 mm.
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