Branched chain fatty acids, their derivatives and use in the treatment of central nervous system disorders
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United States of America Patent
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Jun 26, 2001
Grant Date -
N/A
app pub date -
Apr 11, 2000
filing date -
Jul 9, 1997
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A compound having formula (I): wherein R.sub.1 is a saturated or unsaturated chain of 1-5 carbons in length; and R.sub.2 is a saturated or unsaturated chain of 3-10 carbons in length; and A is selected from the group consisting of COOL and CONR'--R', wherein L is a lipid moiety selected from the group consisting of glycerol, C.sub.3-20 fatty acid monoglycerides, C.sub.3-20 fatty acid diglycerides, hydroxy-C.sub.2-6 -alkyl esters of C.sub.3-20 fatty acids, hydroxy-C.sub.2-6 -alkyl esters of lysophosphatidic acids, lyso plasmalogens, lysophospholipids, lysophosphatidic acid amides, glycerophosphoric acids, sphingolipids, lysophosphatidylethanolamines, and N-mono and N,N-di-(C.sub.1-4)alkyl derivatives of the amines thereof; and R' and R' are each independently selected from the group consisting of hydrogen and a lower alkyl group comprising 1-5 carbon atoms; and pharmaceutically acceptable salts thereof. In addition, there is provided methods for using these compositions. ##STR1##
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