Methods for identifying G protein coupled receptor effectors
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United States of America Patent
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Jul 3, 2001
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N/A
app pub date -
Jan 17, 1996
filing date -
Mar 31, 1993
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Abstract
The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a yeast expression library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.
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