US Patent No: 6,258,360

Number of patents in Portfolio can not be more than 2000

Prodrugs activated by targeted catalytic proteins

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Importance

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Abstract

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Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PROTEINIX, INC.GAITHERSBURG, MD19
WELLSTAT BIOCATALYSIS, LLCGAITHERSBURG, MD20

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Casadei, Jan M Bethesda, MD 4 7
Kamireddy, Balreddy Rockville, MD 13 42
Kenten, John Henry Gaithersburg, MD 6 79
Martin, Mark T Germantown, MD 41 565
Massey, Richard J Rockville, MD 48 957
Napper, Andrew D Natick, MA 13 48
Simpson, David M Adelphia, MD 18 127
Smith, Rodger G Jefferson, MD 15 71
Titmas, Richard C Rockville, MD 14 64
von, Borstel Reid Potomac, MD 11 88
Williams, Richard O Potomac, MD 16 154

Cited Art Landscape

Patent Info (Count) # Cites Year
 
DUPONT MERCK PHARMACEUTICAL COMPANY, THE (1)
* 4,757,062 Substituted benzoate ester prodrugs of estrogens 2 1985
 
BRISTOL-MYERS SQUIBB COMPANY (1)
* 4,975,278 Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells 263 1988
 
Miles Laboratories, Inc. (1)
4,493,890 Activated apoglucose oxidase and its use in specific binding assays 53 1982
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
4,661,586 Monoclonal anti-idiotype antibodies 29 1983
 
HOFFMANN-LA ROCHE INC. (1)
* 4,966,891 Fluorocytidine derivatives 40 1988
 
WELLSTAT BIOCATALYSIS, LLC (3)
4,888,281 Method of catalyzing chemical reactions 44 1984
4,792,446 Production of antibody catalysts 43 1986
4,963,355 Production of antibody catalysts 27 1987
 
BRISTOL-MYERS SQUIBB PHARMA COMPANY (1)
* 4,668,685 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists 37 1985
 
VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (1)
5,411,984 Water soluble analogs and prodrugs of taxol 21 1992
 
HYBRITECH INCORPORATED (2)
4,376,110 Immunometric assays using monoclonal antibodies 830 1980
4,486,530 Immunometric assays using monoclonal antibodies 217 1981
 
The Scripps Research Institute (2)
4,659,567 Molecules with antibody combining sites that bind to hydrolytic transition states 38 1984
4,900,674 Antibody combining sites that exhibit amide or ester synthase activity 25 1987
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
RIGEL PHARMACEUTICALS, INC. (2)
8,546,433 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer 4 2010
* 2010/0196,511 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER 19 2010
 
NUVO RESEARCH INC. (1)
* 2008/0292,729 Stabilized Chlorite Solutions in Combination with Fluoropyrimidines for Cancer Treatment 0 2006
 
The General Hospital Corporation (1)
8,993,295 Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting 0 2007
 
BEHRINGWERKE AKTIENGESELLSCHAFT (3)
* 7,060,495 Fusion proteins for prodrug activation 8 1997
7,273,727 Fusion proteins for prodrug activation 1 2005
* 2006/0292,139 Fusion proteins for prodrug activation 0 2005
* Cited By Examiner