US Patent No: 6,258,360

Number of patents in Portfolio can not be more than 2000

Prodrugs activated by targeted catalytic proteins

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Importance

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Abstract

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Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PROTEINIX, INC.GAITHERSBURG, MD38
WELLSTAT BIOCATALYSIS, LLCGAITHERSBURG, MD42

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Casadei, Jan M Bethesda, MD 4 6
Kamireddy, Balreddy Rockville, MD 15 33
Kenten, John Henry Gaithersburg, MD 6 61
Martin, Mark T Rockville, MD 49 408
Massey, Richard J Rockville, MD 51 815
Napper, Andrew D Hopkinton, MA 12 46
Simpson, David M Adelphi, MD 18 111
Smith, Rodger G Jefferson, MD 16 61
Titmas, Richard C 12905 Crookston La., Apt. 103, Rockville, MD 20851 15 51
Von, Borstel Reid Potomac, MD 12 55
Williams, Richard O London, GB2 11 133

Cited Art Landscape

Patent Info (Count) # Cites Year
 
WELLSTAT BIOCATALYSIS, LLC (3)
4,888,281 Method of catalyzing chemical reactions 43 1984
4,792,446 Production of antibody catalysts 43 1986
4,963,355 Production of antibody catalysts 25 1987
 
HYBRITECH INCORPORATED (2)
4,376,110 Immunometric assays using monoclonal antibodies 741 1980
4,486,530 Immunometric assays using monoclonal antibodies 204 1981
 
Miles Laboratories, Inc. (2)
4,492,751 Heterogenous specific binding assay employing an enzyme substrate as label 36 1979
4,493,890 Activated apoglucose oxidase and its use in specific binding assays 52 1982
 
The Scripps Research Institute (2)
4,659,567 Molecules with antibody combining sites that bind to hydrolytic transition states 38 1984
4,900,674 Antibody combining sites that exhibit amide or ester synthase activity 25 1987
 
BRISTOL-MYERS SQUIBB COMPANY (1)
4,975,278 Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells 223 1988
 
BRISTOL-MYERS SQUIBB PHARMA COMPANY (1)
4,668,685 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists 20 1985
 
DUPONT MERCK PHARMACEUTICAL COMPANY, THE (1)
4,757,062 Substituted benzoate ester prodrugs of estrogens 2 1985
 
HOFFMANN-LA ROCHE INC. (1)
4,966,891 Fluorocytidine derivatives 34 1988
 
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (1)
4,211,773 5-Substituted 1-(2'-Deoxy-2'-substituted-.beta.-D-arabinofuranosyl)pyrimidine nucleosides 51 1978
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
4,661,586 Monoclonal anti-idiotype antibodies 29 1983
 
The Wistar Institute (1)
4,196,265 Method of producing antibodies 278 1978
 
VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (1)
5,411,984 Water soluble analogs and prodrugs of taxol 16 1992

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
BEHRINGWERKE AKTIENGESELLSCHAFT (2)
7,060,495 Fusion proteins for prodrug activation 4 1997
7,273,727 Fusion proteins for prodrug activation 0 2005
 
RIGEL PHARMACEUTICALS, INC. (1)
8,546,433 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer 0 2010