Delivery of biologically active substance to target sites in the body of patients
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Jul 10, 2001
Grant Date -
N/A
app pub date -
Feb 3, 1999
filing date -
Feb 9, 1998
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The invention concerns a method for administering bioactive substances to patients at selected sites in the body and remotely promoting delivery of said media to selected organs or tissues in the body. The method comprises providing an administrable formulation comprising, dispersed in an aqueous carrier liquid, liposomes filled with bioactive substances and gas-filled microspheres, injecting said formulation into the circulation of a patient so that it is directed to a site of interest, and applying ultrasound pulses to said site so as to make the gas-filled microbodies explode and the gas confined therein to expand in the carrier liquid, the energy of expansion of said confined gas causing the liposome vesicles to open and release the trapped substances at said site. Also disclosed are formulations for delivery of biologically active substances to selected target sites in the organism, the formulations comprising an aqueous suspension of gas-filled microvesicles and liposomes filled with active susbstances such as drugs or diagnostic agents. The formulations are available in a kit form in which the kit comprises sterile precursor components.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully