Production of polyketides in bacteria and yeast
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United States of America Patent
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Jul 10, 2001
Grant Date -
N/A
app pub date -
Oct 21, 1999
filing date -
Dec 18, 1996
priority date (Note) -
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Abstract
Hybrid and novel polyketide synthases (PKSs) and polyketides are produced by use of a multiple vector system. The combinatorial possibilities offered by placing the various catalytic activities of PKS systems on separate vectors permits the construction of improved libraries of PKS and polyketides. In addition, polyketides can be produced in hosts that ordinarily do not produce polyketides by supplying, along with an expression system for the desired PKS, an expression system for holo acyl carrier protein (ACP) synthase.
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