Nucleic acids encoding tumor necrosis factor receptor 5

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United States of America Patent

PATENT NO 6261801
SERIAL NO

09006353

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as 'TNFR-5' or 'TR5', and now referred to hereinafter as 'TRAIL receptor without intracellular domain' or 'TRID.' TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

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Patent Owner(s)

Patent OwnerAddress
HUMAN GENOME SCIENCES INC14200 SHADY GROVE ROAD ROCKVILLE MARYLAND 20850-7464 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gentz, Reiner Silver Spring, MD 56 592
Ni, Jian Rockville, MD 459 3712
Ruben, Steven M Olney, MD 693 8435
Wei, Ying-Fei San Mateo, CA 104 455

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