Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells
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United States of America Patent
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Jul 17, 2001
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app pub date -
Jun 23, 2000
filing date -
Jun 25, 1999
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Abstract
The invention includes compositions, kits, and methods for modulating survival and differentiation of mammalian multi-potential hematopoietic progenitor cells using a placental glycoprotein hormone of the murine prolactin family, namely either murine prolactin-like protein E or murine prolactin-like protein F. The compositions, kits, and methods described herein can be used, for example, for in vitro or ex vivo expansion of hematopoietic precursor cells or to treat a disorder associated with aberrant hematopoiesis (e.g., pre-eclampsia and thrombocytopenia).
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