Leptospiral outer membranes protein, LipL46
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United States of America Patent
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Jul 17, 2001
Grant Date -
N/A
app pub date -
Nov 18, 1999
filing date -
Jul 23, 1998
priority date (Note) -
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Abstract
An antigenic preparation is provided containing an outer membrane protein associated with pathogenic strains of Leptospira. The protein has been designated 'LipL46' for 'lipoprotein from Leptospira' and because the isolated polypeptide migrates to a position corresponding to a molecular weight of 46 kD in a denaturing polyacrylamide gel. The invention provides polynucleotides encoding LipL46 and antibodies that bind the protein which are useful in the diagnosis of leptospirosis. In addition, LipL46 can be used immunologically as a vaccine for spirochete-associated pathologies.
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