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United States of America Patent
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Jul 24, 2001
Grant Date -
N/A
app pub date -
Apr 28, 1999
filing date -
Oct 28, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides a composition of matter of the formula (I): V-L-R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotension or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (e.g. .sup.125 I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.
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