Fibrinogen-coated microspheres
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United States of America Patent
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Jul 24, 2001
Grant Date -
N/A
app pub date -
Jun 4, 1998
filing date -
Jun 5, 1997
priority date (Note) -
In Force
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Abstract
The invention provides compositions comprising microspheres of fibrinogen-coated cross-linked albumin microspheres having a size range of primarily from about 100 to about 5000 nanometers diameter, wherein the composition is substantially free microspheres and microsphere aggregates having a diameter of more than 10 micrometers. At least a portion of the fibrinogen on the surface of the microspheres is covalently attached. The particles of the invention are useful for reducing bleeding time when administered to a human or other animal.
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