US Patent No: 6,267,985

Number of patents in Portfolio can not be more than 2000

Clear oil-containing pharmaceutical compositions

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Abstract

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The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a triglyceride and a carrier, where the carrier is formed from a combination of at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous solvent, the composition forms a clear, aqueous dispersion of the triglyceride and surfactants. An optional therapeutic agent can be incorporated into the composition, or can be co-administered with the composition. The invention also provides methods of enhancing triglyceride solubility and methods of treatment with therapeutic agents using these compositions.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
LIPOCINE INC.SALT LAKE CITY, UT14

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Feng-Jing Salt Lake City, UT 30 2055
Patel, Mahesh V Salt Lake City, UT 76 2225

Cited Art Landscape

Patent Info (Count) # Cites Year
 
ATHENA NEUROSCIENCES, INC. (4)
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5,633,226 Convertible microemulsion formulations 31 1995
5,646,109 Convertible microemulsion formulations 29 1995
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R.P. SCHERER CORPORATION (4)
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NOVARTIS AG (3)
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HemaGen/PFC (1)
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HOFFMANN-LA ROCHE INC. (1)
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INSTITUTE FOR ADVANCED SKIN RESEARCH, INC. (1)
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ISP CAPITAL, INC. (1)
5,300,529 Stable, clear, efficacious aqueous microemulsion compositions containing a high loading of a water-insoluble, agriculturally active chemical 15 1993
 
KABI PHARMACIA AB (1)
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MULLER, BERND W. (1)
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Patralan Limited (1)
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PII DRUG DELIVERY, LLC (1)
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T.I.L. Medical Ltd. (1)
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THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (1)
5,766,629 Oral cyclosporin formulations 44 1996
 
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WATSON LABORATORIES, INC. (1)
5,858,401 Pharmaceutical composition for cyclosporines 67 1997
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (1)
5,364,632 Medicinal emulsions 104 1993
 
ZENECA LIMITED (1)
5,731,355 Pharmaceutical compositions of propofol and edetate 47 1997
 
Other [Check patent profile for assignment information] (2)
5,350,741 Enteric formulations of physiologically active peptides and proteins 74 1992
5,653,987 Liquid formulations for proteinic pharmaceuticals 71 1995

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
ALLERGAN, INC. (18)
6,635,654 Ophthalmic compositions containing loratadine 1 2003
7,297,679 Cyclosporin compositions 11 2005
7,276,476 Cyclosporin compositions 11 2005
7,202,209 Cyclosporin compositions 14 2005
7,501,393 Pharmaceutical compositions comprising cyclosporins 10 2005
7,288,520 Cyclosporin compositions 20 2005
8,288,348 Cyclosporin compositions 8 2006
7,745,400 Prevention and treatment of ocular side effects with a cyclosporin 3 2006
8,536,134 Cyclosporin compositions 0 2007
8,211,855 Cyclosporin compositions 9 2007
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8,501,174 Prevention and treatment of ocular side effects with a cyclosporin 0 2010
8,563,518 Cyclosporin compositions 0 2012
8,685,930 Methods of providing therapeutic effects using cyclosporin components 0 2013
8,648,048 Methods of providing therapeutic effects using cyclosporin components 0 2013
8,642,556 Methods of providing therapeutic effects using cyclosporin components 0 2013
8,633,162 Methods of providing therapeutic effects using cyclosporin components 0 2013
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ANTARES PHARMA, IPL, AG (10)
7,425,340 Permeation enhancing compositions for anticholinergic agents 2 2005
7,335,379 Transdermal pharmaceutical formulation for minimizing skin residues 9 2006
8,067,399 Method and apparatus for transdermal or transmucosal application of testosterone 2 2006
7,387,788 Pharmaceutical compositions of nicotine and methods of use thereof 5 2006
7,404,965 Composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels 4 2006
7,470,433 Formulations for transdermal or transmucosal application 14 2007
8,268,346 Methods of treating hot flashes with formulations for transdermal or transmucosal application 0 2007
8,338,400 Methods and apparatus for transdermal or transmucosal application of testosterone 0 2011
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SOFT GEL TECHNOLOGIES, INC. (10)
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8,506,995 Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing 1 2007
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8,658,161 Solubilized CoQ-10 1 2012
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CELLRESIN TECHNOLOGIES, LLC (9)
7,166,671 Grafted cyclodextrin 16 2003
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7,795,333 Grafted cyclodextrin 2 2006
7,365,123 Grafted cyclodextrin 9 2006
7,605,199 Grafted cyclodextrin 1 2006
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8,129,450 Articles having a polymer grafted cyclodextrin 4 2007
 
DEBIOPHARM INTERNATIONAL SA (9)
7,790,709 Heterocyclic compounds, methods of making them and their use in therapy 2 2003
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7,879,872 Compositions comprising multiple bioactive agents, and methods of using the same 3 2005
7,741,339 Fab I inhibitors 3 2007
8,318,720 Acrylamide derivatives as Fab I inhibitors 1 2007
8,263,613 Salts, prodrugs and polymorphs of fab I inhibitors 1 2008
7,790,716 Fab I inhibitors 4 2009
8,153,652 Fab I inhibitors 1 2010
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UNIMED PHARMACEUTICALS, LLC (8)
8,466,136 Testosterone gel and method of use 0 2011
8,466,137 Testosterone gel and method of use 0 2011
8,486,925 Testosterone gel and method of use 1 2011
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GILEAD PHARMASSET LLC (7)
8,173,621 Nucleoside cyclicphosphates 16 2009
8,716,262 Nucleoside phosphoramidates 0 2009
8,716,263 Synthesis of purine nucleosides 0 2009
8,551,973 Nucleoside analogs 4 2009
8,859,756 Stereoselective synthesis of phosphorus containing actives 0 2011
8,841,275 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections 0 2011
8,759,510 Nucleoside cyclicphosphates 0 2012
 
SANTEN PHARMACEUTICAL CO., LTD. (7)
8,637,070 Rapamycin formulations and methods of their use 0 2006
8,492,400 Stable formulations, and methods of their preparation and use 0 2007
8,222,271 Formulations and methods for vascular permeability-related diseases or conditions 0 2007
8,663,639 Formulations for treating ocular diseases and conditions 0 2008
8,367,097 Liquid formulations for treatment of diseases or conditions 2 2010
8,486,960 Formulations and methods for vascular permeability-related diseases or conditions 0 2012
8,658,667 Stable formulations, and methods of their preparation and use 0 2013
 
CEPHALON, INC. (5)
7,297,346 Pharmaceutical formulations of modafinil 3 2002
7,229,644 Pharmaceutical formulations of modafinil 4 2002
8,268,892 Pharmaceutical formulations of modafinil 1 2008
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Clarus Therapeutics, Inc. (5)
8,241,664 Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same 3 2006
8,492,369 Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same 1 2010
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8,778,917 Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same 0 2013
8,828,428 Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same 0 2014
 
EGALET LTD. (4)
8,877,241 Morphine controlled release system 0 2004
8,298,581 Matrix compositions for controlled delivery of drug substances 0 2004
8,617,605 Polymer release system 2 2008
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GALDERMA S.A. (4)
7,915,243 Topical skin care composition 2 2004
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8,247,395 Topical skin care composition 0 2011
8,653,053 Topical skin care composition 0 2012
 
LIPOCINE INC. (4)
6,720,001 Emulsion compositions for polyfunctional active ingredients 73 1999
6,761,903 Clear oil-containing pharmaceutical compositions containing a therapeutic agent 47 2001
8,778,922 Steroidal compositions 0 2012
8,865,695 Steroidal compositions 0 2014
 
VIRUN, INC. (4)
8,765,661 Compositions containing non-polar compounds 0 2009
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ABBVIE INC. (3)
8,728,516 Stabilized lipid formulation of apoptosis promoter 0 2010
8,362,013 Salt of ABT-263 and solid-state forms thereof 0 2010
8,691,878 Solid pharmaceutical dosage form 0 2012
 
NAIDU LP (3)
7,956,031 Metallo-lactoferrin-coenzyme compositions for trigger and release of bioenergy 8 2006
8,021,659 Coenzyme Q10, lactoferrin and angiogenin compositions and uses thereof 3 2006
8,476,223 Metallo-lactoferrin-coenzyme compositions to improve sleep patterns 0 2011
 
OTSUKA PHARMACEUTICAL CO., LTD. (3)
7,825,130 PTEN inhibitor or Maxi-K channels opener 0 2004
8,329,731 PTEN inhibitor or Maxi-K channels opener 0 2009
8,653,104 PTEN inhibitor or Maxi-K channels opener 0 2012
 
WATSON LABORATORIES, INC. (3)
7,988,995 Pharmaceutical compositions for lipophilic drugs 5 2002
8,119,157 Pharmaceutical compositions for lipophilic drugs 0 2006
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ARENA PHARMACEUTICALS, INC. (2)
8,362,248 Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto 0 2006
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DEXCEL LTD. (2)
7,026,290 Dispersible concentrate for the delivery of cyclosprin 4 1999
7,732,404 Pro-nanodispersion for the delivery of cyclosporin 0 2006
 
GALEPHAR PHARMACEUTICAL RESEARCH, INC. (2)
7,435,427 Pharmaceutical semi-solid composition of isotretinoin 0 2001
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PAUL ROYALTY FUND, L.P. (2)
7,097,849 Injectable aqueous dispersions of propofol 1 1999
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PBM PHARMACEUTICALS, INC. (2)
8,075,910 Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions 1 2005
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RTP PHARMA INC. (2)
6,979,456 Anticancer compositions 21 1999
6,726,919 Injectable dispersion of propofol 15 2001
 
Supernus Pharmaceuticals, Inc. (2)
7,011,846 Oral capsule formulation with increased physical stability 5 2002
7,022,337 Self-emulsifying formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability and/or reduced food effect 7 2003
 
ABBOTT PRODUCTS GMBH (1)
8,802,087 Pharmaceutical compositions of lipase-containing products, in particular of pancreation 0 2005
 
B. BRAUN MEDICAL, INC. (1)
7,323,206 Reagents and methods for all-in-one total parenteral nutrition for neonates and infants 2 2004
 
BEIERSDORF AG (1)
7,052,716 Cosmetic and dermatological preparations comprising an effective content of bile acids, their salts and/or their derivatives 0 1999
 
BEND RESEARCH, INC. (1)
8,703,204 Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer 0 2008
 
BORKAN, LIONEL (1)
8,287,904 Stable soft capsule dosage form for acetylsalicylic acid 0 2010
 
CANON KABUSHIKI KAISHA (1)
8,833,363 Ejection liquid, ejection method, method for forming liquid droplets, liquid ejection cartridge and ejection apparatus 0 2010
 
CARGILL, INCORPORATED (1)
6,623,780 Aqueous dispersible sterol product 15 2002
 
CHRISTINE ANDERSEN (1)
8,609,143 Morphine polymer release system 3 2008
 
CYDEX PHARMACEUTICALS, INC. (1)
6,869,939 Formulations containing amiodarone and sulfoalkyl ether cyclodextrin 1 2002
 
DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER, UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, THE (1)
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GENERAL TOPICS S.R.L. (1)
7,169,811 Composition based on ethyl ester of linoleic acid and triethyl ester of citric acid for topical use in the treatment of seborrhea and acne 0 2002
 
Gilead Pharmassel LLC (1)
8,563,530 Purine nucleoside phosphoramidate 1 2011
 
HILL DERMACEUTICALS (1)
7,544,674 Topical skin care composition 2 2002
 
HILL DERMACEUTICALS, INC. (1)
7,169,401 Topical skin care composition containing refined peanut oil 2 2004
 
HOVID BERHAD (1)
6,596,306 Drug delivery system:formulation for fat-soluble drugs 2 2000
 
INSYS PHARMA, INC. (1)
8,628,796 Room-temperature stable dronabinol formulations 0 2005
 
INTELGENX CORP. (1)
8,735,374 Oral mucoadhesive dosage form 0 2010
 
ISIS PHARMACEUTICALS, INC. (1)
8,039,444 Antisense permeation enhancers 0 2006
 
IVAX PHARMACEUTICALS S.R.O. (1)
8,673,351 Crystallization inhibitor and its use in gelatin capsules 0 2006
 
KEMIN INDUSTRIES, INC. (1)
8,603,568 Hydrolyzed lecithin product to improve digestibility 0 2011
 
LODERS CROKLAAN USA LLC (1)
7,582,317 Food supplements comprising, as a health component, sargahydroquinoic acid or derivative thereof 0 2002
 
LUPIN ATLANTIS HOLDINGS, S.A. (1)
8,026,281 Treating metabolic syndrome with fenofibrate 0 2005
 
LYFJATHROUN HF. (1)
6,855,332 Absorption promoting agent 3 2002
 
NICOX S.A. (1)
7,815,933 Self emulsifying drug delivery system 0 2002
 
NICOX SCIENCE IRELAND (1)
7,736,666 Self emulsifying drug delivery system 0 2001
 
NITTO DENKO CORPORATION (1)
8,003,621 Drug carriers 5 2008
 
NOSTRUM PHARMACEUTICALS, INC. (1)
7,897,179 Pharmaceutical composition containing water soluble drug 2 2004
 
PFIZER PRODUCTS INC. (1)
8,309,129 Nanoparticles comprising a drug, ethylcellulose, and a bile salt 0 2008
 
PLIVA, INC. (1)
7,452,552 Pharmaceutical compositions for lipophilic drugs 0 2007
 
PROMETIC BIOSCIENCES INC. (1)
7,745,488 Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors 0 2002
 
RPG LIFE SCIENCES LIMITED (1)
7,056,530 Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities 0 2000
 
SAMSUNG ELECTRO-MECHANICS CO., LTD. (1)
7,414,441 Output buffer circuit 1 2006
 
SANOFI (1)
6,528,539 Stable formulation containing fumagillin 1 2001
 
SIGMOID PHARMA LIMITED (1)
8,535,713 Pharmaceutical cyclosporin compositions 0 2008
 
TEVA WOMEN'S HEALTH, INC. (1)
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THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (1)
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TRANSFORM PHARMACEUTICALS, INC. (1)
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UNIVERSITI PUTRA MALAYSIA (1)
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UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (1)
6,559,139 Combination chemotherapy 5 2000
 
ZOETIS W LLC (1)
7,687,471 Benzimidazole non-aqueous compositions 0 2006
 
Other [Check patent profile for assignment information] (6)
7,338,971 Treatment of inflammatory, cancer, and thrombosis disorders 0 2001
7,374,772 Topical antifungal treatment 0 2002
8,148,416 Treatment of inflammatory, cancer, and thrombosis disorders 4 2008
8,895,536 Compositions and methods for treating chronic inflammation and inflammatory diseases 0 2012
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