Clear oil-containing pharmaceutical compositions

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6267985
SERIAL NO

09345615

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a triglyceride and a carrier, where the carrier is formed from a combination of at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous solvent, the composition forms a clear, aqueous dispersion of the triglyceride and surfactants. An optional therapeutic agent can be incorporated into the composition, or can be co-administered with the composition. The invention also provides methods of enhancing triglyceride solubility and methods of treatment with therapeutic agents using these compositions.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
LIPOCINE INC.SALT LAKE CITY, UT18

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Feng-Jing Salt Lake City, UT 36 3251
Patel, Mahesh V Salt Lake City, UT 92 3850

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
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5665379 Lipid particle forming matrix, preparation and use thereof 35 1994
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NOVARTIS AG (3)
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* Cited By Examiner

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DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER, UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, THE (1)
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* 2004/0037,911 Genital lubricating compositions and uses thereof 9 2003
 
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* 6761903 Clear oil-containing pharmaceutical compositions containing a therapeutic agent 97 2001
* 2003/0104,048 Pharmaceutical dosage forms for highly hydrophilic materials 129 2002
* 2005/0096,365 Pharmaceutical compositions with synchronized solubilizer release 13 2003
* 2006/0034,937 Solid carriers for improved delivery of active ingredients in pharmaceutical compositions 50 2005
* 2010/0136,105 PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ADMINISTRATION OF HYDROPHOBIC DRUGS 36 2009
9034858 High-strength testosterone undecanoate compositions 4 2012
8778922 Steroidal compositions 5 2012
8865695 Steroidal compositions 3 2014
9358241 High-strength testosterone undecanoate compositions 0 2014
9205057 High-strength testosterone undecanoate compositions 3 2015
9498485 Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters 0 2015
9480690 High-strength testosterone undecanoate compositions 0 2015
 
HILL DERMACEUTICALS (3)
7544674 Topical skin care composition 3 2002
* 2004/0081,668 Topical skin care composition 0 2002
* 2005/0101,580 Topical skin care composition 6 2004
 
BEND RESEARCH, INC. (4)
8703204 Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer 32 2008
9545384 Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate 0 2008
8974827 Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer 0 2008
9233078 Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer 0 2008
 
JUPITAR PTY LTD (1)
* 2004/0167,034 Emulsion and dispersion formulations and method 9 2004
 
Otsuka Pharmaceutical Co., Ltd. (4)
* 7825130 PTEN inhibitor or Maxi-K channels opener 1 2004
* 2006/0154,963 Pten inhibitor or maxi-k channels opener 2 2004
8329731 PTEN inhibitor or Maxi-K channels opener 0 2009
8653104 PTEN inhibitor or Maxi-K channels opener 0 2012
 
HILL DERMACEUTICALS, INC. (4)
7169401 Topical skin care composition containing refined peanut oil 2 2004
* 2005/0053,635 Topical skin care composition containing refined peanut oil 0 2004
* 2007/0140,999 TOPICAL SKIN CARE COMPOSITION CONTAINING REFINED PEANUT OIL 38 2007
9480691 Topical liquid containing refined peanut oil for treating skin proliferation or inflammation disorders 0 2012
 
STRIDES ARCOLAB LIMITED (1)
* 2006/0286,164 Pharmaceutical composition containing a stable and clear solution of anti-inflammatory drug in soft gelatin capsule and process for producing the same 0 2004
 
TOPPAN PRINTING CO., LTD. (1)
* 2006/0183,257 Method for analyzing electrolytic copper plating solution, and analyzing device therefor and production method for semi-conductor product 1 2004
 
GP PHARM S.A. (1)
* 2011/0130,446 INJECTABLE TAXANE PHARMACEUTICAL COMPOSITION 2 2009
 
EMS S.A. (2)
* 9278065 Delivery systems for solubilising water-insoluble pharmaceutical active ingredients 0 2008
* 2012/0177,692 DELIVERY SYSTEMS FOR SOLUBILISING WATER-INSOLUBLE PHARMACEUTICAL ACTIVE INGREDIENTS 0 2008
 
CANON KABUSHIKI KAISHA (3)
* 2007/0248,571 Ejection Liquid, Ejection Method, Method for Forming Liquid Droplets, Liquid Ejection Cartridge and Ejection Apparatus 6 2005
8833363 Ejection liquid, ejection method, method for forming liquid droplets, liquid ejection cartridge and ejection apparatus 0 2010
* 2011/0079,223 EJECTION LIQUID, EJECTION METHOD, METHOD FOR FORMING LIQUID DROPLETS, LIQUID EJECTION CARTRIDGE AND EJECTION APPARATUS 0 2010
 
ARCHER-DANIELS-MIDLAND COMPANY (1)
* 2003/0228,395 Isotropic transparent structured fluids 3 2003
 
INTOCELL DISTRIBUTORS, LLC (1)
* 2010/0041,622 Compositions containing aminoalkanes and aminoalkane derivatives 17 2009
 
INTELGENX CORP. (3)
8735374 Oral mucoadhesive dosage form 0 2010
* 2011/0028,431 ORAL MUCOADHESIVE DOSAGE FORM 0 2010
* 2011/0136,815 SOLID ORAL FILM DOSAGE FORMS AND METHODS FOR MAKING SAME 2 2010
 
SANGUIBIOTECH GMBH (1)
* 2005/0232,953 Microemulsions having a binary phase differentiability and active substance differentiability, the production thereof and their use, particularly for the topical supply of oxygen 9 2004
 
LEO PHARMA A/S (2)
* 2013/0023,501 PHARMACEUTICAL COMPOSITION COMPRISING SOLVENT MIXTURE AND A VITAMIN D DERIVATIVE OR ANALOGUE 0 2010
* 2012/0322,776 CUTANEOUS COMPOSITION COMPRISING VITAMIN D ANALOGUE AND A MIXTURE OF SOLVENT AND SURFACTANTS 0 2010
 
CJ CORPORATION (1)
* 2005/0118,254 Microemulsion preconcentrate 29 2004
 
INFIRST HEALTHCARE LIMITED (9)
8895536 Compositions and methods for treating chronic inflammation and inflammatory diseases 15 2012
8895537 Compositions and methods for treating cardiovascular diseases 3 2012
9308213 Solid solution compositions and use in chronic inflammation 0 2014
9271950 Compositions for treating chronic inflammation and inflammatory diseases 0 2014
9265742 Compositions and methods for treating inflammatory pain 0 2014
9427422 Compositions for treating cardiovascular diseases 0 2014
9381180 Compositions and methods for treating chronic inflammation and inflammatory diseases 0 2014
9326958 Compositions for treating chronic inflammation and inflammatory diseases 0 2014
9504664 Compositions and methods for treating severe pain 0 2015
 
BIOMAX, INC. (1)
* 2004/0110,667 Carrier system for cyclosporin pharmaceutical compositions 2 2003
 
GENERAL TOPICS S.R.L. (2)
* 7169811 Composition based on ethyl ester of linoleic acid and triethyl ester of citric acid for topical use in the treatment of seborrhea and acne 1 2002
* 2003/0118,623 Composition based on etyl ester of linoleic acid and triethyl ester of citric acid for topical use in the treatment of seborrhea and acne 4 2002
 
University of Pittsburgh (1)
6559139 Combination chemotherapy 6 2000
 
Ronald G. Udell (1)
* 2006/0013,888 Solubilized CoQ-10 13 2005
 
PBM PHARMACEUTICALS, INC. (3)
8075910 Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions 3 2005
* 8173160 Compositions comprising edible oils and vitamins and/or minerals and methods for making the compositions 2 2005
* 2008/0274,175 Compositions Comprising Edible Oils and Vitamins and/or Minerals and Methods for Making the Compositions 5 2005
 
AVENTIS PHARMA S.A. (2)
* 2005/0025,792 Self-emulsifying and self-microemulsifying formulations for the oral administration of taxoids 2 2004
* 2009/0069,411 SELF-EMULSIFYING AND SELF-MICROEMULSIFYING FORMULATIONS FOR THE ORAL ADMINISTRATION OF TAXOIDS 0 2008
 
ALLERGAN, INC. (33)
6635654 Ophthalmic compositions containing loratadine 1 2003
* 7297679 Cyclosporin compositions 17 2005
7276476 Cyclosporin compositions 16 2005
7202209 Cyclosporin compositions 19 2005
* 2007/0015,710 Cyclosporin compositions 5 2005
* 2007/0015,692 Cyclosporin compositions 6 2005
* 2007/0015,691 Cyclosporin compositions 12 2005
* 2007/0015,693 Cyclosporin compositions 5 2005
* 2007/0015,690 Cyclosporin compositions 0 2005
7501393 Pharmaceutical compositions comprising cyclosporins 14 2005
* 2007/0027,072 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLOSPORINS 8 2005
7288520 Cyclosporin compositions 27 2005
* 2007/0015,694 Cyclosporin compositions 9 2005
* 8288348 Cyclosporin compositions 12 2006
7745400 Prevention and treatment of ocular side effects with a cyclosporin 3 2006
* 2007/0167,358 PREVENTION AND TREATMENT OF OCULAR SIDE EFFECTS WITH A CYCLOSPORIN 3 2006
8536134 Cyclosporin compositions 3 2007
8211855 Cyclosporin compositions 13 2007
8575108 Cyclosporin compositions 1 2007
* 2008/0070,834 Cyclosporin Compositions 11 2007
8906861 Pharmaceutical compositions comprising cyclosporins 0 2009
8501174 Prevention and treatment of ocular side effects with a cyclosporin 0 2010
* 2010/0266,622 PREVENTION AND TREATMENT OF OCULAR SIDE EFFECTS WITH A CYCLOSPORIN 0 2010
8563518 Cyclosporin compositions 3 2012
8685930 Methods of providing therapeutic effects using cyclosporin components 2 2013
8648048 Methods of providing therapeutic effects using cyclosporin components 2 2013
8642556 Methods of providing therapeutic effects using cyclosporin components 3 2013
8633162 Methods of providing therapeutic effects using cyclosporin components 3 2013
8629111 Methods of providing therapeutic effects using cyclosporin components 2 2013
8969306 Cyclosporin compositions 0 2013
9101574 Cyclosporin compositions 1 2013
8969307 Cyclosporin compositions 0 2013
9248191 Methods of providing therapeutic effects using cyclosporin components 0 2014
 
CHIASMA, INC. (1)
* 2005/0058,702 Compositions capable of facilitating penetration across a biological barrier 17 2003
 
PHARMACIA CORPORATION (1)
* 2005/0187,278 Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors 1 2004
 
NITTO DENKO CORPORATION (1)
8003621 Drug carriers 6 2008
 
JAGOTEC AG (1)
* 2004/0151,776 Novel compositions 0 2003
 
CYDEX PHARMACEUTICALS, INC. (5)
6869939 Formulations containing amiodarone and sulfoalkyl ether cyclodextrin 4 2002
* 2005/0250,738 Taste-masked formulations containing sertraline and sulfoalkyl ether cyclodextrin 13 2005
* 2007/0020,298 Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid 7 2006
* 2007/0020,299 Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid 24 2006
* 2009/0312,724 Nasal and Ophthalmic Delivery of Aqueous Corticosteroid Solutions 19 2009
 
Borkan, Lionel (1)
* 8287904 Stable soft capsule dosage form for acetylsalicylic acid 0 2010
 
KEMIN INDUSTRIES, INC. (2)
8603568 Hydrolyzed lecithin product to improve digestibility 1 2011
* 2011/0177,194 Hydrolyzed Lecithin Product to Improve Digestibility 0 2011
 
ZOETIS SERVICES LLC (4)
* 7687471 Benzimidazole non-aqueous compositions 0 2006
* 2007/0128,239 Benzimidazole non-aqueous compositions 1 2006
9283176 Benzimidazole anthelmintic compositions 0 2009
* 2010/0087,497 Benzimidazole Anthelmintic Compositions 0 2009
 
DEXCEL LTD. (2)
7026290 Dispersible concentrate for the delivery of cyclosprin 7 1999
7732404 Pro-nanodispersion for the delivery of cyclosporin 0 2006
 
UNIVERSITI PUTRA MALAYSIA (2)
* 8598236 Emulsion system derived from engkabang fat esters 0 2010
* 2012/0165,415 EMULSION SYSTEM DERIVES FROM ENGKABANG FAT ESTERS 0 2010
 
UNIMED PHARMACEUTICALS, LLC (8)
8466136 Testosterone gel and method of use 2 2011
8466137 Testosterone gel and method of use 2 2011
8486925 Testosterone gel and method of use 2 2011
8466138 Testosterone gel and method of use 3 2011
8759329 Testosterone gel and method of use 0 2013
8754070 Testosterone gel and method of use 0 2013
8741881 Testosterone gel and method of use 0 2013
8729057 Testosterone gel and method of use 0 2013
 
SANOFI (1)
* 6528539 Stable formulation containing fumagillin 2 2001
 
HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (1)
* 2004/0258,623 Insulin-containing oral spray and the preparation method thereof 1 2004
 
Lyfjathroun hf. (3)
6855332 Absorption promoting agent 14 2002
* 2004/0005,275 Absorption promoting agent 8 2002
* 2005/0063,940 Bioadhesive agent 0 2004
 
LODERS CROKLAAN USA LLC (3)
* 7582317 Food supplements comprising, as a health component, sargahydroquinoic acid or derivative thereof 0 2002
* 2003/0129,294 Blends comprising a substituted fatty acid or a derivative thereof 5 2002
* 2010/0029,766 Blends Comprising a Substituted Fatty Acid or a Derivative Thereof 1 2009
 
SEMBIOSYS GENETICS INC. (1)
* 2008/0241,082 Method for the Preparation of Cosmetic Emulsion 3 2005
 
RPG LIFE SCIENCES LIMITED (1)
* 7056530 Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities 0 2000
 
Gilead Pharmassel LLC (1)
8563530 Purine nucleoside phosphoramidate 17 2011
 
ARENA PHARMACEUTICALS, INC. (4)
8362248 Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto 1 2006
* 2007/0167,473 Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto 20 2006
8410119 Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto 1 2009
8933083 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia 0 2012
 
STERIX LIMITED (1)
* 2004/0147,494 Use 1 2004
 
ABBVIE INC. (6)
8728516 Stabilized lipid formulation of apoptosis promoter 0 2010
8362013 Salt of ABT-263 and solid-state forms thereof 0 2010
* 2010/0305,125 SALT OF ABT-263 AND SOLID-STATE FORMS THEREOF 3 2010
* 2010/0311,751 SOLID DISPERSIONS CONTAINING AN APOPTOSIS-PROMOTING AGENT 6 2010
8927009 ABT-263 capsule 0 2010
8691878 Solid pharmaceutical dosage form 1 2012
 
DR. REDDY'S LABORATORIES LIMITED (1)
9572819 Oral composition of celecoxib for treatment of pain 0 2016
 
CHUGAI SEIYAKU KABUSHIKI KAISHA (1)
* 2007/0129,340 Ed-71 preparation 1 2005
 
NOSTRUM PHARMACEUTICALS, INC. (2)
7897179 Pharmaceutical composition containing water soluble drug 8 2004
8906419 Pharmaceutical composition containing water soluble drug 0 2011
 
RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES (1)
* 2009/0137,617 USE OF HAPTOGLOBIN GENOTYPING IN DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASE 0 2008
 
HORIZON PHARMA AG (2)
* 2010/0222,312 DELAYED-RELEASE GLUCOCORTICOID TREATMENT OF ASTHMA 2 2010
* 2010/0196,427 DELAYED-RELEASE GLUCOCORTICOID TREATMENT OF RHEUMATOID ARTHRITIS BY IMPROVING SIGNS AND SYMPTOMS, SHOWING MAJOR OR COMPLETE CLINICAL RESPONSE AND BY PREVENTING FROM JOINT DAMAGE 2 2010
 
GALDERMA S.A. (5)
7915243 Topical skin care composition 3 2004
7939516 Topical skin care composition 2 2007
8247395 Topical skin care composition 0 2011
8653053 Topical skin care composition 0 2012
9333172 Topical skin care composition 0 2014
 
EASTMAN CHEMICAL COMPANY (1)
* 2006/0240,051 Eutectic blends containing a water soluble vitamin derivative 1 2005
 
EGALET LTD. (14)
8877241 Morphine controlled release system 2 2004
* 8298581 Matrix compositions for controlled delivery of drug substances 1 2004
* 2007/0042,044 Matrix compositions for controlled delivery of drug substances 28 2004
* 2010/0291,205 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR MITIGATING RISK OF ALCOHOL INDUCED DOSE DUMPING OR DRUG ABUSE 18 2008
8617605 Polymer release system 9 2008
* 2008/0254,122 Polymer release system 10 2008
* 2010/0166,866 MATRIX COMPOSITIONS FOR CONTROLLED DELIVERY OF DRUG SUBSTANCES 27 2009
9005660 Immediate release composition resistant to abuse by intake of alcohol 2 2010
9023394 Formulations and methods for the controlled release of active drug substances 1 2013
9549899 Abuse deterrent pharmaceutical compositions for controlled release 0 2013
8808745 Morphine polymer release system 6 2013
9044402 Abuse-deterrent pharmaceutical compositions for controlled release 1 2014
9375428 Morphine controlled release system 0 2014
9358295 Immediate release composition resistant to abuse by intake of alcohol 1 2015
* Cited By Examiner