US Patent No: 6,267,985
Number of patents in Portfolio can not be more than 2000
Clear oil-containing pharmaceutical compositions
Stats
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Jul 31, 2001
Issued date -
Jun 30, 1999
filing date -
09/345,615
serial no -
In Force
status
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Abstract
The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a triglyceride and a carrier, where the carrier is formed from a combination of at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous solvent, the composition forms a clear, aqueous dispersion of the triglyceride and surfactants. An optional therapeutic agent can be incorporated into the composition, or can be co-administered with the composition. The invention also provides methods of enhancing triglyceride solubility and methods of treatment with therapeutic agents using these compositions.
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First Claim
Related Publications
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International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 5,444,041 Convertible microemulsion formulations | 85 | 1992 | |
| 5,633,226 Convertible microemulsion formulations | 25 | 1995 | |
| 5,646,109 Convertible microemulsion formulations | 22 | 1995 | |
| 5,707,648 Transparent liquid for encapsulated drug delivery | 73 | 1995 | |
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| 4,727,109 Pharmaceutical preparation with an active substance of low solubility in water and gastric juices | 20 | 1985 | |
| 5,071,643 Solvent system enhancing the solubility of pharmaceuticals for encapsulation | 44 | 1987 | |
| 5,376,688 Enhanced solubility pharmaceutical solutions | 26 | 1992 | |
| 5,645,856 Delivery systems for hydrophobic drugs | 77 | 1995 | |
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| 4,388,307 Galenical compositions | 121 | 1982 | |
| 5,342,625 Pharmaceutical compositions comprising cyclosporins | 175 | 1992 | |
| 5,589,455 Cyclosporin-containing soft capsule compositions | 51 | 1995 | |
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| 5,665,379 Lipid particle forming matrix, preparation and use thereof | 22 | 1994 | |
| 5,626,869 Pharmaceutical composition containing a defined lipid system | 25 | 1995 | |
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| 5,206,219 Oral compositions of proteinaceous medicaments | 127 | 1991 | |
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| 5,120,710 Oral lipid medicinal composition | 21 | 1990 | |
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| 4,572,915 Clear micellized solutions of fat soluble essential nutrients | 37 | 1984 | |
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| 5,741,822 Mixed lipid-bicarbonate colloidal particles for delivering drugs | 12 | 1994 | |
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| 5,726,181 Formulations and compositions of poorly water soluble camptothecin derivatives | 39 | 1995 | |
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| 4,713,246 Etoposide oral dosage form | 21 | 1986 | |
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| 4,994,439 Transmembrane formulations for drug administration | 104 | 1989 | |
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| 5,639,474 Cyclosporin soft capsule composition | 35 | 1995 | |
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| 5,616,330 Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same | 30 | 1994 | |
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| 5,747,066 Mixed micelles | 13 | 1996 | |
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| 5,948,825 Microemulsion preparation containing a slightly absorbable substance | 5 | 1995 | |
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| 5,300,529 Stable, clear, efficacious aqueous microemulsion compositions containing a high loading of a water-insoluble, agriculturally active chemical | 13 | 1993 | |
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| 5,244,925 Emulsion for parenteral administration | 16 | 1991 | |
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| 5,686,105 Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery | 26 | 1995 | |
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| 5,656,277 Nor- and homo- bile acids derivatives as absorption enhancers for medicaments | 11 | 1994 | |
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| 4,719,239 Pharmaceutical multicomponent systems and method of preparing same | 99 | 1985 | |
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| 5,656,289 Pharmaceutical formulations that have a biologically active hydrophilic phase and a chylomicra-containing hydrophobic phase | 37 | 1994 | |
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| 5,532,002 Gelatin pharmaceutical formulations | 33 | 1994 | |
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| 5,614,491 Liquid preparations containing cyclosporin and process for preparing same | 34 | 1994 | |
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| 5,639,724 Cyclosporin galenic forms | 67 | 1993 | |
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| 5,145,684 Surface modified drug nanoparticles | 448 | 1991 | |
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| 4,944,949 Pharmaceutical delivery systems | 61 | 1987 | |
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| 5,817,320 In ovo immunization of avian embryos with oil-emulsion vaccines | 13 | 1996 | |
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| 5,766,629 Oral cyclosporin formulations | 32 | 1996 | |
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| 4,731,384 Etofenamate formulation | 16 | 1986 | |
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| 5,858,401 Pharmaceutical composition for cyclosporines | 42 | 1997 | |
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| 5,364,632 Medicinal emulsions | 99 | 1993 | |
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| 5,731,355 Pharmaceutical compositions of propofol and edetate | 39 | 1997 | |
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| 5,350,741 Enteric formulations of physiologically active peptides and proteins | 61 | 1992 | |
| 5,653,987 Liquid formulations for proteinic pharmaceuticals | 65 | 1995 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jan 31, 2013 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |