Biotherapeutic virus attenuation using variable frequency microwave energy
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United States of America Patent
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Jul 31, 2001
Grant Date -
N/A
app pub date -
Jan 15, 1999
filing date -
Jan 15, 1999
priority date (Note) -
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Abstract
Virus attenuation is performed on a lyophilized biotherapeutic sealed within a microwave permeable container without harming the biotherapeutic and without exposing the biotherapeutic to additional viruses, by subjecting the container and biotherapeutic therewithin to variable frequency microwave energy. The container and biotherapeutic therewithin are swept with at least one range of microwave frequencies. Each range of microwave frequencies has a central frequency selected to break apart helix strands of a nucleic acid of the virus, to modify a capsid enclosing a nucleic acid of the virus, or to selectively couple to water molecules inside the capsid without harming the biotherapeutic or the container.
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