Bicyclonucleoside and oligonucleotide analogues

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United States of America Patent

PATENT NO 6268490
SERIAL NO

09380638

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Abstract

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An oligo- or polynucleotide analogue having one or more structures of the general formula ##STR1## where B is a pyrimidine or purine nucleic acid base, or an analogue thereof, is disclosed. The use of this analogue provides an oligonucleotide analogue antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized.

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Patent Owner(s)

Patent OwnerAddress
ROCHE INNOVATION CENTER COPENHAGEN A/SDANISH HOLM HOLTH HOERSHOLM REGION HOVEDSTADEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Imanishi, Takeshi Nara-ken, JP 31 2293
Obika, Satoshi Osaka, JP 50 1737

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