Cancer treatment by expression of differentiation factor receptor
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United States of America Patent
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Aug 7, 2001
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N/A
app pub date -
Mar 12, 1997
filing date -
Sep 21, 1994
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Expired
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Abstract
Disclosed are methods of reducing or inhibiting the motility and/or proliferative abilities of a neural tumor cell, or of enhancing apoptosis or differentiation of the tumor cell, in which a vector comprising a nucleic acid encoding a cytoplasmic domain of a neurotrophin receptor tyrosine kinase, is transferred to the tumor cell such that the nucleic acid is expressed. The methods of the invention result in reduced tumorigenicity of neural tumors.
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