US Patent No: 6,271,255

Number of patents in Portfolio can not be more than 2000

Erythromycins and process for their preparation

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ALSO PUBLISHED AS: 20010016598
ATTORNEY / AGENT: (SPONSORED)
 

Importance

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Abstract

Erythromycins, particularly with C-13 substituents R1 (e.g. C.sub.3 -C.sub.6 cycloalkyl or cycloalkenyl groups) are prepared by fermenting suitable organisms in the presence of R.sub.1 CO.sub.2 H. A preferred organism is Saccharopolyspora erythraea preferably containing an integrated plasmid capable of directing synthesis of desired compounds.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BIOTICA TECHNOLOGY LIMITEDCAMBRIDGE26

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cortes, Jesus Cambridge, GB 8 53
Leadlay, Peter Francis Cambridge, GB 20 61
Pacey, Michael Stephen Sandwich, GB 8 64
Staunton, James Cambridge, GB 17 62

Cited Art

Patent Info (Count) # Cites Year
 
ABBOTT LABORATORIES (5)
5,141,926 Erythromycin derivatives 36 1990
5,824,513 Recombinant DNA method for producing erythromycin analogs 85 1991
6,004,787 Method of directing biosynthesis of specific polyketides 32 1995
6,060,234 Polyketide derivatives and recombinant methods for making same 30 1997
6,063,561 Polyketide derivatives and recombinant methods for making same 24 1998
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (4)
5,672,491 Recombinant production of novel polyketides 159 1994
5,843,718 Recombinant production of novel polyketides 48 1997
6,022,731 Recombinant production of novel polyketides 30 1997
6,066,721 Method to produce novel polyketides 38 1997
 
JOHN INNES CENTRE (2)
5,712,146 Recombinant combinatorial genetic library for the production of novel polyketides 93 1995
5,962,290 Recombinant production of novel polyketides 51 1997
 
THE JOHN INNES INSTITUTE (1)
5,830,750 Recombinant production of novel polyketides 48 1997

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
KOSAN BIOSCIENCES, INC. (12)
6,403,775 Erythronolide compounds 10 1999
6,399,789 Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides 9 2000
6,451,768 Macrolide antiinfective agents 5 2000
6,395,710 Macrolide antiinfective agents 10 2000
6,514,944 Macrolide antiinfective agents 6 2000
6,828,126 Methods for introducing hydroxyl or epoxide groups into polyketides using OleP 0 2001
6,593,302 Macrolide antiinfective agents 5 2002
6,794,366 Macrolide antiinfective agents 2 2002
6,939,861 Amido macrolides 1 2003
6,762,168 Macrolide antiinfective agents 4 2003
7,459,294 Method of producing a compound by fermentation 0 2004
RE39836 Macrolide antinfective agents 0 2005
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (12)
6,391,594 Modified modular PKS with retained scaffold 11 1997
6,558,942 Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold 5 1998
6,500,960 Method to produce novel polyketides 4 1999
6,753,173 Methods to mediate polyketide synthase module effectiveness 0 2000
6,461,838 Recombinant production of novel polyketides 2 2001
6,984,515 Macrolide analogs 0 2001
6,927,057 Macrolide analogs 0 2001
6,969,611 Methods to prepare cells comprising heterologous polyketide synthase expression systems 0 2001
7,001,748 Methods of making polyketides using hybrid polyketide synthases 0 2002
7,101,684 Modified modular polyketide synthase 0 2004
7,312,048 Recombinant production of novel polyketides 0 2005
7,741,456 Polyketides and antibiotics produced by combinatorial techniques 0 2006
 
SCHERING-PLOUGH PTY. LIMITED (5)
7,312,248 Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives 0 2005
7,705,038 Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives 0 2005
8,119,667 Carbonates of fenicol antibiotics 0 2006
8,084,643 Water-soluble prodrugs of florfenicol and its analogs 0 2007
8,044,230 Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof 0 2007
 
BIOTICA TECHNOLOGY LIMITED (3)
6,960,453 Hybrid polyketide synthases combining heterologous loading and extender modules 0 1999
7,049,100 Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides 0 2002
7,807,418 Method for producing hybrid polyketide synthases 0 2004
 
PFIZER INC. (3)
7,015,203 Macrolides 0 2002
6,825,171 Erythromycin derivatives 1 2003
6,777,543 13-methyl erythromycin derivatives 2 2003
 
ORTHO-MCNEIL PHARMACEUTICAL, INC. (2)
6,458,771 Ketolide antibacterials 6 2000
6,590,083 Ketolide antibacterials 7 2000
 
INTERVET INTERNATIONAL B.V. (1)
8,314,252 Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol 0 2009
 
JOHN INNES CENTRE (1)
6,399,382 Recombinant production of novel polyketides 3 1999

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