RNA targeted 2'-modified oligonucleotides that are conformationally preorganized
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United States of America Patent
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Aug 7, 2001
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N/A
app pub date -
Jul 27, 1998
filing date -
Jul 27, 1998
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Abstract
2'-O-modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclosed. Oligonucleotides are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2'-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3' endo geometries.
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