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Abstract

The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R.sub.1).sub.n represents 1 or 2 substituents, which can be the same or different, from the group C.sub.1-3 -alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C.sub.1-2)amino, or two groups R.sub.1 at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R.sub.2).sub.p represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R.sub.2).sub.p is a methylene bridge or ethylene bridge, R.sub.3 is hydrogen or methyl, and (R).sub.m represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C.sub.1-3 -alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C.sub.1-2)amino, on the understanding that R.sub.1 cannot represent o-OCH.sub.3 when X is nitrogen, (R.sub.2).sub.p and R.sub.3 are hydrogen, m is 0 and n is 1 ##STR1##

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First Claim