Apparatus and method for removing small molecules and ions from low volume biological samples
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United States of America Patent
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Sep 4, 2001
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N/A
app pub date -
Dec 22, 1999
filing date -
Dec 22, 1999
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Abstract
This invention provides an apparatus and method for desalting a low volume solution for use in connection with an electronically addressable microarray. The apparatus comprises a tubular molecular weight cut-off membrane embedded within a ion exchange resin filled chamber. The apparatus provides a very high surface to volume ratio of membrane pore surface to exchange resin capacity for absorbing charged molecules. The design facilitates the speedy removal of charged molecules from test solutions with the resultant desalted solution having a very low ionic strength suitable for use in the electronic transport of nucleic acids, proteins, and cells.
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