Plasmid-based vaccine for treating atherosclerosis
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United States of America Patent
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Sep 4, 2001
Grant Date -
N/A
app pub date -
Oct 2, 1998
filing date -
May 1, 1996
priority date (Note) -
Expired
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Abstract
A plasmid-based vaccine is provided herein based on the combination of DNA segments coding for one or more B cell epitopes of cholesteryl ester transfer protein (CETP) and one or more broad range helper T cell epitopes. Administration of the plasmids as a vaccine to a vertebrate subject provides an immune response to the subject's endogenous CETP and modulation of CETP activity, leading to prevention or reversal of various manifestations of heart disease. The vaccines provide an advantageous strategy for the prevention or treatment of atherosclerosis.
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