Micromechanical antibody sensor

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United States of America Patent

PATENT NO 6289717
SERIAL NO

09281032

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A sensor apparatus is provided using a microcantilevered spring element having a coating of a detector molecule such as an antibody or antigen. A sample containing a target molecule or substrate is provided to the coating. The spring element bends in response to the stress induced by the binding which occurs between the detector and target molecules. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0 .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers.

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Patent Owner(s)

Patent OwnerAddress
LOCKHEED MARTIN ENERGY RESEARCH CORPORATION701 SCARBORO RD OAK RIDGE TN 37831

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Doktycz, Mitchel J Knoxville, TN 24 608
Jacobson, K Bruce Oak Ridge, TN 5 173
Kennel, Stephen J Oak Ridge, TN 8 154
Thundat, Thomas G Knoxville, TN 40 1615
Warmack, Robert J Knoxville, TN 27 979

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