Methods for the preparation of 4-hydroxybenzothiophene
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United States of America Patent
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Sep 18, 2001
Grant Date -
N/A
app pub date -
Jul 26, 2000
filing date -
Aug 2, 1999
priority date (Note) -
Expired
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Abstract
The present invention is concerned with a novel process for the preparation of the hydroxybenzothiophene of formula I ##STR1## comprising cyclocarbonylation of a compound of formula II ##STR2## wherein Y is as defined in the specification, followed by saponification. The compound of Formula I is a building block of pharmaceutically active substances, e.g. 5-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-7-benzothiophenylmethyl]-2,4-thiazolidinedione and the corresponding sodium salt which are from agents useful in the treatment of diabetes.
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