Bioerodable polymeric adhesives for tissue repair
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United States of America Patent
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Oct 9, 2001
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N/A
app pub date -
Apr 16, 1996
filing date -
Apr 16, 1996
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Abstract
Improved matrices for tissue repair comprising a biocompatible, bioerodable polymer which has a water solubility of about 0.01 to about 500 mg/mL at about 25.degree. C. and adhesive strength of about 600 to about 150,000 Pa; and pressure sensitive adhesives for tissue repair which have adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both. The matrices and adhesives are tissue-adherent and dough-like so they can be molded to fit a repair site. When used for bone/implant fixation, or as a filler for bone or cartilage repair, gradual short-term bioerosion of the adhesive matrix allows it to be replaced with developing bone or cartilage tissue. When used for release of a bioactive agent, the agent can be mixed into the adhesive matrix well before the implantation procedure. After implantation, the bioactive agent is gradually released as the adhesive matrix biodegrades.
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