FTCD antigen
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United States of America Patent
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Oct 9, 2001
Grant Date -
N/A
app pub date -
Aug 13, 1999
filing date -
Feb 14, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to FTCD antigen which is liver specific to serve as a diagnostic tool for Autoimmune Hepatitis type II. There is provided a human liver specific FTCD antigen recognized by LC1 antibodies which essentially consists in the amino acid sequence of SEQ ID NOS:3 and 4 or variants thereof which are recognized by LC1 antibodies. There is also disclosed a method of diagnosis of Autoimmune Hepatitis (AIH) type II disease in a patient biological sample, which comprises the steps of: a) subjecting a Western Blot having bound thereto an FTCD antigen of the present invention with the patient biological sample; and b) detecting the presence of LC1 antibodies in the sample; whereby the presence of LC1 antibodies is indicative of AIH type II disease.
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