Modular probe for total internal reflection fluorescence spectroscopy

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United States of America Patent

PATENT NO 6300638
SERIAL NO

09189841

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Abstract

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An instrument for total internal reflection fluorescence spectroscopy having modular probe that inexpensively monitors vapors and liquid-phase analytes under field conditions is described. The system is particularly helpful in evaluating multiple analytes using the fluorescence of a material immobilized in a thin sorbent polymer coating. At the same time, the system is capable of monitoring trace quantities of analyte using a fluorescence-read immunological reaction. The device includes a diode laser source, a shaped optical element (which may be as simple as a microscope slide), and one or more amplified photodiode detectors. The shaped optical element propagates light from the diode laser in a series of internally reflective bounces.

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Patent Owner(s)

Patent OwnerAddress
VERIDIAN ENGINEERING INCSUITE 1100 1200 SOUTH HAYES STREET ARLINGTON VA 22202

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coolbaugh, Myron T Christiansburg, VA 2 82
Groger, Howard P Gainesville, FL 23 842
Lo, K Peter Blacksburg, VA 15 371
Raymonda, John Las Cruces, NM 2 68
Reynolds, Roger L Blasdell, NY 4 86
Sullivan, William F Cheektowaga, NY 19 281

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