Calcification-resistant biomaterials
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United States of America Patent
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Oct 16, 2001
Grant Date -
N/A
app pub date -
Jul 31, 1996
filing date -
Jul 31, 1996
priority date (Note) -
Expired
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Abstract
The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than about 0.5 mg metal cations per gram of biocompatible material. The calcification inhibitors preferably decrease calcium deposition by greater than 95% relative to untreated tissue. The calcification inhibitors are bonded to the bioprosthetic material preferably at a pH between about 6.0 and 8.5.
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