Methods for disease diagnosis from stool samples
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United States of America Patent
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Oct 16, 2001
Issued Date -
N/A
app pub date -
Feb 2, 1999
filing date -
Aug 14, 1996
priority date (Note) -
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Abstract
The present invention provides methods for preparing a stool sample in order to screen for the presence of indicators of a disease, for example a subpopulation of cancerous or precancerous cells. The methods take advantage of the recognition that cellular debris from cancerous and precancerous cells is deposited onto only a longitudinal stripe of stool as the stool is forming in the colon. Accordingly, methods of the invention comprise obtaining a representative sample, such as a circumferential or cross-sectional sample of stool in order to ensure that any disease indicator, such as cellular debris that is shed by colonic cells, is obtained in the sample.
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