Template-directed photoligation
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United States of America Patent
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Oct 23, 2001
Issued Date -
N/A
app pub date -
Nov 10, 1997
filing date -
Jan 13, 1988
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Methods, apparatus and compositions are presented for ligating ligands together which bind to a common receptor. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive group in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.
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