Importance

Loading Importance Indicators...

Abstract

The invention refers to pharmaceutical compositions suitable for the protection of the mitochondrial genom and/or mitochondrium from damages or for the treatment of diseases connected with such damages, said compositions comprising a hydroximic acid derivative of the formula: ##STR1## wherein R.sup.1 represents a hydrogen or a C.sub.1-5 alkyl group, R.sup.2 stands for a hydrogen, a C.sub.1-5 alkyl group, a C.sub.3-8 cycloalkyl group or a phenyl group optionally substituted by a hydroxy or a phenyl group, or R.sup.1 or R.sup.2 together with the nitrogen atom they are attached to form a 5 to 8 membered ring optionally containing one or more further nitrogen, oxygen or sulfur atom(s) and said ring can be condensed with another alicyclic or heterocyclic ring, preferably a benzene, naphthalene, quinoline, isoquinoline, pyridine or pyrazoline ring, furthermore, if desired and chemically possible, the nitrogen and/or sulfur heteroatom(s) are present in the form of an oxide or dioxide, R.sup.3 means a hydrogen, a phenyl group, a naphthyl group or a pyridyl group wherein said groups can be substituted by one or more halo atom(s) or C.sub.1-4 alkoxy group(s), Y is a hydrogen, a hydroxy group, a C.sub.1-24 alkoxy group optionally substituted by an amino group, a C.sub.2-24 polyalkenyl-oxy group containing 1 to 6 double bond(s), a C.sub.1-25 alkanoyl group, C.sub.3-9 alkenoyl group or a group of the formula R.sup.7 --COO--, wherein R.sup.7 represents a C.sub.2-30 polyalkenyl group containing 1 to 6 double bond(s), X stands for a halo, an amino group, a C.sub.1-4 alkoxy group, or X forms with B an oxygen atom, or X and Y together with the carbon atoms they are attached to and the --NR--O--CH.sub.2 group being between said carbon atoms form a ring of the formula ##STR2## wherein Z represents an oxygen or a nitrogen, R stands for a hydrogen or R forms with B a chemical bond, A is a C.sub.1-4 alkylene group or a chemical bond or a group of the formula ##STR3## wherein R.sup.4 represents a hydrogen, a C.sub.1-5 alkyl group, a C.sub.3-8 cycloalkyl group or a phenyl group optionally substituted by a halo, a C.sub.1-4 alkoxy group or a C.sub.1-5 alkyl group, R.sup.5 stands for a hydrogen, a C.sub.1-4 alkyl group or a phenyl group, m has a value of 0, 1 or 2, n has a value of 0, 1 or 2, or a pharmaceutically acceptable acid addition salt thereof as the active ingredient.

Loading the Abstract Image...

First Claim