Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening
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United States of America Patent
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Oct 30, 2001
Grant Date -
N/A
app pub date -
Nov 24, 1999
filing date -
Nov 24, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A stimulator for electrically inducing a maximal seizure in a test animal for screening candidate anticonvulsant drugs is disclosed. A stimulator according to this invention includes stimulus generation and control circuitry for generating the stimulus, a display for displaying the duration of three phases of the induced seizure, and user input configured to allow the user to control delivery of the stimulus and to record seizure phase transitions to be displayed on the display. The stimulator may also include a foot switch, electrodes, a computer interface and an optional computer. A method of measuring the phases of an electrically induced seizure is disclosed. A method of analyzing the efficacy of a candidate anticonvulsant drug is also disclosed.
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