Pulmonary insulin crystals
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United States of America Patent
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Oct 30, 2001
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N/A
app pub date -
Mar 20, 1998
filing date -
Mar 20, 1997
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Abstract
The present invention relates to zinc free insulin crystals having a diameter below 10 .mu.m and to therapeutic powder formulations suitable for pulmonary administration containing such insulin crystals. The crystals of the present invention exhibit a better stability profile than powders of essentially the same composition prepared by spray drying, freeze-drying, vacuum drying and open drying. The therapeutic powder formulations elucidate better flowing properties than corresponding amorphous powder formulations.
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