Importance

Loading Importance Indicators...

Abstract

The present invention provides novel compounds of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are H, OH, F, Cl, Br, I, 1 to 6 carbon alkyl or alkenyl, 1 to 6 carbon alkoxy, aryl, OR.sub.5, nitro, amino, CF.sub.3 or R.sub.1 and R.sub.2 are taken together to form a fused ring at the 2,3- or 3,4-positions providing a fused phenyl group or a benzodioxane group, or a 4- or 7-substituted indole group, or a 4- or 5- or 8-substituted quinoline group; R.sub.3 represents a group selected from hydrogen, a 1 to 6 carbon alkyl, a 1 to 4 carbon alkoxy or a halogen; R.sub.4 represents a group selected from hydrogen, 1 to 6 carbon alkyl or R.sub.5 ; R.sub.5 is CH.sub.2 Ph in which the phenyl ring can be optionally substituted by a group selected from OMe, halogen, CF.sub.3 ; X is selected from a group represented by N, CR.sub.4, CHR.sub.4 and CHCH; A is selected from a group represented by N, NH, CH and CH.sub.2 ; B is selected from a group represented by .dbd.O, .dbd.S, H and H2; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of treating central nervous system disorders utilizing these compounds.

Loading the Abstract Image...

First Claim