Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist
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United States of America Patent
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Oct 30, 2001
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app pub date -
Aug 29, 1997
filing date -
Oct 19, 1995
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Abstract
An analgesic composition is disclosed comprising a sub-analgesic dosage of a .mu.-opioid agonist, optionally in the form of a pharmaceutically acceptable salt, and a sub-analgesic dosage of a .kappa..sub.2 -opioid agonist, optionally in the form of a pharmaceutically acceptable salt. There is also disclosed a method for producing analgesia in humans and lower animals which comprises administering concurrently to a human or lower animal in need of such treatment an analgesic composition of the invention.
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